U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LEU9 2-isopropylmalate synthase LEU9 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854275, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
LEU9
Official Full Name
2-isopropylmalate synthase LEU9
Primary source
SGD:S000005634
Locus tag
YOR108W
See related
AllianceGenome:SGD:S000005634; FungiDB:YOR108W; VEuPathDB:YOR108W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 2-isopropylmalate synthase activity. Involved in L-leucine biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LEU9 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (523027..524841)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene SNAP receptor VAM3 Neighboring gene GTPase-activating protein RGS2 Neighboring gene phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 Neighboring gene transcription factor TFIIIC subunit TFC7

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification by functional analysis of the gene encoding alpha-isopropylmalate synthase II (LEU9) in Saccharomyces cerevisiae. Casalone E, et al. Yeast, 2000 Apr. PMID 10790691
  2. Diversification of Paralogous α-Isopropylmalate Synthases by Modulation of Feedback Control and Hetero-Oligomerization in Saccharomyces cerevisiae. López G, et al. Eukaryot Cell, 2015 Jun. PMID 25841022, Free PMC Article
  3. Metabolomic approach for improving ethanol stress tolerance in Saccharomyces cerevisiae. Ohta E, et al. J Biosci Bioeng, 2016 Apr. PMID 26344121
  4. The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix. Prohl C, et al. Mol Cell Biol, 2001 Feb. PMID 11158296, Free PMC Article
  5. Roles of dom34:hbs1 in nonstop protein clearance from translocators for normal organelle protein influx. Izawa T, et al. Cell Rep, 2012 Sep 27. PMID 22981232

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2-isopropylmalate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-isopropylmalate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-isopropylmalate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-isopropylmalate synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 2-isopropylmalate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-leucine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in L-leucine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
2-isopropylmalate synthase LEU9
NP_014751.1
  • Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    523027..524841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183527.1 → NP_014751.1  TPA: 2-isopropylmalate synthase LEU9 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014751.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2G7, Q12166
    UniProtKB/TrEMBL
    B3LJF1, N1NWK7
    Conserved Domains (1) summary
    TIGR00970
    Location:34 → 596
    leuA_yeast; 2-isopropylmalate synthase, yeast type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12166.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools