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LPL1 putative hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854225, updated on 18-Sep-2024

Summary

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Official Symbol
LPL1
Official Full Name
putative hydrolase
Primary source
SGD:S000005585
Locus tag
YOR059C
See related
AllianceGenome:SGD:S000005585; FungiDB:YOR059C; VEuPathDB:YOR059C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-10
Summary
Enables lysophospholipase activity. Involved in lipid homeostasis. Located in lipid droplet. Orthologous to human FAM135A (family with sequence similarity 135 member A) and FAM135B (family with sequence similarity 135 member B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LPL1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (438906..440258, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ase1p Neighboring gene tRNA-Lys Neighboring gene Sld7p Neighboring gene casein kinase 2 catalytic subunit CKA2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a phospholipase B encoded by the LPL1 gene in Saccharomyces cerevisiae. Selvaraju K, et al. Biochim Biophys Acta, 2014 Oct. PMID 25014274
  2. The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast. Jin F, et al. Sci Rep, 2017 Sep 19. PMID 28928489, Free PMC Article
  3. Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae. Wagner A, et al. Biochim Biophys Acta, 2009 Feb. PMID 19111628
  4. Phospholipase Lpl1 links lipid droplet function with quality control protein degradation. Weisshaar N, et al. Mol Biol Cell, 2017 Mar 15. PMID 28100635, Free PMC Article
  5. Analysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins. Metzger MB, et al. Mol Biol Cell, 2009 Feb. PMID 19073890, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. regulation of Dam1 phosphorylation imposed by Ipl1 kinase is critical for faithful chromosome segregation.
    Title: The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative hydrolase
NP_014702.1
  • Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    438906..440258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183478.1 → NP_014702.1  TPA: putative hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014702.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2C2, O00022, Q08448
    UniProtKB/TrEMBL
    A6ZNR1, B5VRV7, C7GX59, C8ZI20, G2WMT7, N1NWV9
    Conserved Domains (1) summary
    pfam05057
    Location:5 → 209
    DUF676; Putative serine esterase (DUF676)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08448.1

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