CKB2 casein kinase 2 regulatory subunit CKB2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CKB2
Official Full Name: casein kinase 2 regulatory subunit CKB2
Primary source: SGD:S000005565
Locus tag: YOR039W
See related: AllianceGenome:SGD:S000005565; FungiDB:YOR039W; VEuPathDB:YOR039W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein serine/threonine kinase inhibitor activity. Involved in DNA damage response; regulation of transcription by RNA polymerase I; and regulation of transcription by RNA polymerase III. Part of CURI complex; UTP-C complex; and protein kinase CK2 complex. Orthologous to human CSNK2B (casein kinase 2 beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CKB2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (405768..406544)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Title: The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2α indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
CK2 activity is directly correlated to growth rate and not to the carbon source.
Title: CK2 activity is modulated by growth rate in Saccharomyces cerevisiae.
CK2 phosphorylates up to six serine residues in highly acidic peptide K199EVIPESDEEESSADEDDNEDEDEESGDSEEESGSEEESDSEEVEITYED248 of the Svf1 protein in vitro.
Title: Yeast surviving factor Svf1 as a new interacting partner, regulator and in vitro substrate of protein kinase CK2.
These data may help to elucidate the role of yeast protein kinase CK2beta/beta' subunits in the regulation of holoenzyme assembly and phosphotransferase activity.
Title: Yeast holoenzyme of protein kinase CK2 requires both beta and beta' regulatory subunits for its activity.
Yeast transcription elongation factor Elf1 has been identified as a new substrate for protein kinase CK2 and coimmunoprecipitation shows that Elf1 interacts with catalytic (alpha and alpha') as well as regulatory (beta and beta') subunits of CK2.
Title: Yeast elf1 factor is phosphorylated and interacts with protein kinase CK2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CURI complex	IDA Inferred from Direct Assay more info	PubMed
part_of UTP-C complex	IBA Inferred from Biological aspect of Ancestor more info
part_of UTP-C complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein kinase CK2 complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: casein kinase 2 regulatory subunit CKB2

NP_014682.1

Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

405768..406544

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183458.1 → NP_014682.1 TPA: casein kinase 2 regulatory subunit CKB2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014682.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2A6, P38930

UniProtKB/TrEMBL

A6ZNP5, B3LJ92, B5VRU0, C7GLG8, C8ZI01, G2WMS1, N1NWG7

Conserved Domains (1) summary

COG5041
Location:12 → 258

SKB2; Casein kinase II, beta subunit [Signal transduction mechanisms / Cell division and chromosome partitioning / Transcription]