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HIR2 Hir2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854203, updated on 3-Nov-2024

Summary

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Official Symbol
HIR2
Official Full Name
Hir2p
Primary source
SGD:S000005564
Locus tag
YOR038C
See related
AllianceGenome:SGD:S000005564; FungiDB:YOR038C; VEuPathDB:YOR038C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SPT1
Summary
Enables transcription corepressor activity. Contributes to DNA binding activity and nucleosome binding activity. Involved in negative regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase III; and transcription elongation-coupled chromatin remodeling. Located in cytosol and nucleus. Part of HIR complex. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HIR2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (402761..405388, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene SNAP receptor PEP12 Neighboring gene oxidoreductase Neighboring gene casein kinase 2 regulatory subunit CKB2 Neighboring gene hydroxyacylglutathione hydrolase GLO4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to nucleosome binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation-coupled chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of HIR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HIR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HIR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hir2p
NP_014681.1
  • Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    402761..405388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183457.1 → NP_014681.1  TPA: Hir2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014681.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2A5, P32480
    UniProtKB/TrEMBL
    B3LJ91
    Conserved Domains (3) summary
    sd00039
    Location:123 → 163
    7WD40; WD40 repeat [structural motif]
    pfam07569
    Location:581 → 816
    Hira; TUP1-like enhancer of split
    cl29593
    Location:172 → 350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32480.2

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