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TSR4 Tsr4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854136, updated on 18-Sep-2024

Summary

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Official Symbol
TSR4
Official Full Name
Tsr4p
Primary source
SGD:S000005382
Locus tag
YOL022C
See related
AllianceGenome:SGD:S000005382; FungiDB:YOL022C; VEuPathDB:YOL022C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables unfolded protein binding activity. Involved in maturation of SSU-rRNA. Located in cytoplasm. Orthologous to several human genes including PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TSR4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (280272..281498, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene translation initiation factor 2 Neighboring gene tRNA-Gly Neighboring gene exosome catalytic subunit DIS3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the DNA sequence of a 34,038 bp region on the left arm of yeast chromosome XV. Rad MR, et al. Yeast, 1997 Mar 15. PMID 9090058
  2. yRACK1/Asc1 proxiOMICs-Towards Illuminating Ships Passing in the Night. Schmitt K, et al. Cells, 2019 Nov 4. PMID 31689955, Free PMC Article
  3. Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Ben-Aroya S, et al. Mol Cell, 2008 Apr 25. PMID 18439903, Free PMC Article
  4. Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rps2 in Saccharomyces cerevisiae. Black JJ, et al. Mol Cell Biol, 2019 Sep 1. PMID 31182640, Free PMC Article
  5. Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis. Burroughs AM, et al. Front Genet, 2014. PMID 25566315, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tsr4p
NP_014620.1
  • Cytoplasmic assembly chaperone for ribosomal protein Rps2p; co-translationally associates with the N-terminal extension of Rps2p to facilitate expression, solubility and ribosome assembly; released prior to the nuclear import of Rps2p; required for correct processing of 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in the S288C background but not in CEN.PK2; homologous to human PDCD2L and PDCD2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    280272..281498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183276.2 → NP_014620.1  TPA: Tsr4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014620.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W243, P25040
    UniProtKB/TrEMBL
    B3LJ34, B5VRM9, C7GJZ3, C8ZHU1, G2WMK9, N1NWS1
    Conserved Domains (1) summary
    pfam04194
    Location:282 → 404
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25040.2

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