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IFM1 translation initiation factor 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854135, updated on 2-Nov-2024

Summary

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Official Symbol
IFM1
Official Full Name
translation initiation factor 2
Primary source
SGD:S000005383
Locus tag
YOL023W
See related
AllianceGenome:SGD:S000005383; FungiDB:YOL023W; VEuPathDB:YOL023W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity; tRNA binding activity; and translation initiation factor activity. Involved in mitochondrial translation. Located in mitochondrion. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See IFM1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (278056..280086)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Lag2p Neighboring gene uncharacterized protein Neighboring gene Tsr4p Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the C2 subdomain of yeast mitochondrial initiation factor 2. Garofalo C, et al. Arch Biochem Biophys, 2005 Jul 1. PMID 15935987
  2. Purification and characterization of yeast mitochondrial initiation factor 2. Garofalo C, et al. Arch Biochem Biophys, 2003 May 15. PMID 12729623
  3. Mammalian mitochondrial initiation factor 2 supports yeast mitochondrial translation without formylated initiator tRNA. Tibbetts AS, et al. J Biol Chem, 2003 Aug 22. PMID 12799364
  4. Mitochondrial translational-initiation and elongation factors in Saccharomyces cerevisiae. Vambutas A, et al. Eur J Biochem, 1991 Nov 1. PMID 1935960
  5. Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNA(fMet). Franco LVR, et al. FEBS J, 2019 Apr. PMID 30767393

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
translation initiation factor 2
NP_014619.1
  • Mitochondrial translation initiation factor 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    278056..280086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183277.1 → NP_014619.1  TPA: translation initiation factor 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014619.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W242, P25038, Q12693
    UniProtKB/TrEMBL
    B3LJ33, C8ZHU0, N1P2T9
    Conserved Domains (2) summary
    COG0532
    Location:141 → 676
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam04760
    Location:63 → 114
    IF2_N; Translation initiation factor IF-2, N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25038.2

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