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MDM38 ribosome-binding protein MDM38 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854130, updated on 2-Nov-2024

Summary

Official Symbol
MDM38
Official Full Name
ribosome-binding protein MDM38
Primary source
SGD:S000005387
Locus tag
YOL027C
See related
AllianceGenome:SGD:S000005387; FungiDB:YOL027C; VEuPathDB:YOL027C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MKH1
Summary
Enables mitochondrial ribosome binding activity. Involved in several processes, including intracellular potassium ion homeostasis; monoatomic cation transport; and protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial inner membrane. Used to study Wolf-Hirschhorn syndrome and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to several human genes including LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See MDM38 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (272003..273724, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Yap7p Neighboring gene Mim1p Neighboring gene tRNA-Ser

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
ribosome-binding protein MDM38
NP_014615.1
  • Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    272003..273724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183281.1NP_014615.1  TPA: ribosome-binding protein MDM38 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014615.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W238, Q08179
    UniProtKB/TrEMBL
    N1P2T3
    Conserved Domains (2) summary
    pfam07766
    Location:83353
    LETM1; LETM1-like protein
    NF033838
    Location:364507
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form