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SMC5 DNA repair ATPase SMC5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854123, updated on 18-Sep-2024

Summary

Official Symbol
SMC5
Official Full Name
DNA repair ATPase SMC5
Primary source
SGD:S000005394
Locus tag
YOL034W
See related
AllianceGenome:SGD:S000005394; FungiDB:YOL034W; VEuPathDB:YOL034W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATP hydrolysis activity; damaged DNA binding activity; and single-stranded DNA binding activity. Contributes to SUMO transferase activity. Involved in chromosome separation; recombinational repair; and resolution of recombination intermediates. Located in nucleus. Part of Smc5-Smc6 complex. Orthologous to human SMC5 (structural maintenance of chromosomes 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SMC5 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (259923..263204)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene glutamate--tRNA ligase MSE1 Neighboring gene Opi10p

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to SUMO transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in recombinational repair IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in resolution of DNA recombination intermediates IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Smc5-Smc6 complex IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA repair ATPase SMC5
NP_014608.1
  • Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    259923..263204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183288.1NP_014608.1  TPA: DNA repair ATPase SMC5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W231, Q08204
    UniProtKB/TrEMBL
    N1NWC8
    Conserved Domains (1) summary
    COG1196
    Location:421069
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]