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NGL1 RNA exonuclease [ Saccharomyces cerevisiae S288C ]

Gene ID: 854115, updated on 18-Sep-2024

Summary

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Official Symbol
NGL1
Official Full Name
RNA exonuclease
Primary source
SGD:S000005402
Locus tag
YOL042W
See related
AllianceGenome:SGD:S000005402; FungiDB:YOL042W; VEuPathDB:YOL042W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable endonuclease activity and poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Located in mitochondrion. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NGL1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (249825..250916)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Pex15p Neighboring gene bifunctional N-glycosylase/AP lyase NTG2 Neighboring gene Nop12p Neighboring gene ribosomal 40S subunit protein S15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae. Faber AW, et al. RNA, 2002 Sep. PMID 12358428, Free PMC Article
  2. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. Dupressoir A, et al. BMC Genomics, 2001. PMID 11747467, Free PMC Article
  3. Yeast mitochondrial RNase P, RNase Z and the RNA degradosome are part of a stable supercomplex. Daoud R, et al. Nucleic Acids Res, 2012 Feb. PMID 22034500, Free PMC Article
  4. A genomic analysis of chronological longevity factors in budding yeast. Burtner CR, et al. Cell Cycle, 2011 May 1. PMID 21447998, Free PMC Article
  5. Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. Srikumar T, et al. J Cell Biol, 2013 Apr 1. PMID 23547032, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA exonuclease
NP_014600.1
  • Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    249825..250916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183296.1 → NP_014600.1  TPA: RNA exonuclease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W224, Q08213
    UniProtKB/TrEMBL
    A6ZNG7, B3LJ16, B5VRL1, C7GK11, G2WMJ1, N1NWR0
    Conserved Domains (1) summary
    COG5239
    Location:1 → 363
    CCR4; mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08213.1

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