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PEX15 Pex15p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854113, updated on 2-Nov-2024

Summary

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Official Symbol
PEX15
Official Full Name
Pex15p
Primary source
SGD:S000005404
Locus tag
YOL044W
See related
AllianceGenome:SGD:S000005404; FungiDB:YOL044W; VEuPathDB:YOL044W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PAS21
Summary
Enables protein-membrane adaptor activity. Involved in protein import into peroxisome matrix, receptor recycling. Located in peroxisomal membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PEX15 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (247150..248301)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Lds2p Neighboring gene serine/threonine protein kinase PSK2 Neighboring gene bifunctional N-glycosylase/AP lyase NTG2 Neighboring gene RNA exonuclease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane. Elgersma Y, et al. EMBO J, 1997 Dec 15. PMID 9405362, Free PMC Article
  2. Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes. Birschmann I, et al. Mol Biol Cell, 2003 Jun. PMID 12808025, Free PMC Article
  3. The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1. Ali BA, et al. J Biol Chem, 2024 Jan. PMID 38036174, Free PMC Article
  4. An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae. Elgersma Y, et al. Genetics, 1993 Nov. PMID 7507454, Free PMC Article
  5. A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum. Lam SK, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21098289, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1.
    Title: The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1.
  2. Pex1/Pex6 heterohexameric motor is a protein translocase that unfolds Pex15 in a pore-loop-dependent and ATP-hydrolysis-dependent manner
    Title: The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.
  3. In yeast, PEX26 follows the pathway that also ensures correct targeting of Pex15: PEX26 enters the endoplasmic reticulum (ER) in a GET-dependent and Pex19-independent manner.
    Title: Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins.
  4. Mutants of PEX1, PEX6, and PEX15 accumulate ubiquitinated receptors at the peroxisomal membrane. This accumulation has been suggested to trigger pexophagy in mammalian cells.
    Title: Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-membrane adaptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-membrane adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into peroxisome matrix, receptor recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pex15p
NP_014598.1
  • Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    247150..248301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183298.1 → NP_014598.1  TPA: Pex15p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014598.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W222, Q08215
    UniProtKB/TrEMBL
    G2WMI9, N1NVP5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08215.1

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