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PRS5 ribose phosphate diphosphokinase subunit PRS5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854093, updated on 14-Nov-2024

Summary

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Official Symbol
PRS5
Official Full Name
ribose phosphate diphosphokinase subunit PRS5
Primary source
SGD:S000005422
Locus tag
YOL061W
See related
AllianceGenome:SGD:S000005422; FungiDB:YOL061W; VEuPathDB:YOL061W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process. Located in cytoplasm. Part of ribose phosphate diphosphokinase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PRS5 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (212244..213734)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Crt10p Neighboring gene Apm4p Neighboring gene Mam3p Neighboring gene glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of a 26 kb region on the left arm of yeast chromosome XV. Mannhaupt G, et al. Yeast, 1996 Jan. PMID 8789261
  2. The contribution of the nonhomologous region of Prs1 to the maintenance of cell wall integrity and cell viability. Ugbogu EA, et al. FEMS Yeast Res, 2013 May. PMID 23368839
  3. Heterooligomeric phosphoribosyl diphosphate synthase of Saccharomyces cerevisiae: combinatorial expression of the five PRS genes in Escherichia coli. Hove-Jensen B. J Biol Chem, 2004 Sep 24. PMID 15280369
  4. The importance of the five phosphoribosyl-pyrophosphate synthetase (Prs) gene products of Saccharomyces cerevisiae in the maintenance of cell integrity and the subcellular localization of Prs1p. Schneiter R, et al. Microbiology (Reading), 2000 Dec. PMID 11101685
  5. Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. Hernando Y, et al. J Biol Chem, 1999 Apr 30. PMID 10212224

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribose phosphate diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribose phosphate diphosphokinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of ribose phosphate diphosphokinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribose phosphate diphosphokinase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribose phosphate diphosphokinase subunit PRS5
NP_014580.1
  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    212244..213734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183316.1 → NP_014580.1  TPA: ribose phosphate diphosphokinase subunit PRS5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W206, Q12265
    UniProtKB/TrEMBL
    A6ZNE9, B3LIZ8, C7GK28, C8ZHQ2, G2WMH3, N1NZ60
    Conserved Domains (1) summary
    COG0462
    Location:2 → 493
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12265.1

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