APM4 Apm4p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: APM4
Official Full Name: Apm4p
Primary source: SGD:S000005423
Locus tag: YOL062C
See related: AllianceGenome:SGD:S000005423; FungiDB:YOL062C; VEuPathDB:YOL062C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AMP1
Summary: Predicted to enable clathrin adaptor activity. Predicted to be involved in clathrin-dependent endocytosis. Located in cytosol. Part of AP-2 adaptor complex. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IC Inferred by Curator more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AP-2 adaptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
part_of membrane coat	IEA Inferred from Electronic Annotation more info

NP_014579.1

Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals

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The following sections contain reference sequences that belong to a specific genome build. Explain