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MET22 3'(2'),5'-bisphosphate nucleotidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854090, updated on 3-Nov-2024

Summary

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Official Symbol
MET22
Official Full Name
3'(2'),5'-bisphosphate nucleotidase
Primary source
SGD:S000005425
Locus tag
YOL064C
See related
AllianceGenome:SGD:S000005425; FungiDB:YOL064C; VEuPathDB:YOL064C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HAL2
Summary
Enables 3'(2'),5'-bisphosphate nucleotidase activity. Involved in several processes, including hyperosmotic salinity response; methionine biosynthetic process; and tRNA decay. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Orthologous to human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MET22 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (206103..207176, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2 Neighboring gene phosphoinositide 5-phosphatase INP54 Neighboring gene Crt10p Neighboring gene Apm4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A nucleotide metabolite controls stress-responsive gene expression and plant development. Chen H, et al. PLoS One, 2011. PMID 22028934, Free PMC Article
  2. Novel 3'-phosphoadenosine-5'-phosphatases from extremely halotolerant Hortaea werneckii reveal insight into molecular determinants of salt tolerance of black yeasts. Vaupotic T, et al. Fungal Genet Biol, 2007 Nov. PMID 17420146
  3. Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. York JD, et al. Proc Natl Acad Sci U S A, 1995 May 23. PMID 7761465, Free PMC Article
  4. A salt-sensitive 3'(2'),5'-bisphosphate nucleotidase involved in sulfate activation. Murguía JR, et al. Science, 1995 Jan 13. PMID 7809627
  5. Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene. Gläser HU, et al. EMBO J, 1993 Aug. PMID 8393782, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data revealed the genes ESP1 and MET22 as two, so far unknown, genetic determinants of resuming proliferation upon exposure to acetic acid.
    Title: Identification of novel genes involved in acetic acid tolerance of Saccharomyces cerevisiae using pooled-segregant RNA sequencing.
  2. Overexpression of HAL2 in bdf1Delta mutant proterin increases gene expression in the iron-acquisition pathway.
    Title: HAL2 overexpression induces iron acquisition in bdf1Δ cells and enhances their salt resistance.
  3. Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
    Title: Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'(2'),5'-bisphosphate nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hyperosmotic salinity response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate assimilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA decay IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3'(2'),5'-bisphosphate nucleotidase
NP_014577.1
  • Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    206103..207176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183319.1 → NP_014577.1  TPA: 3'(2'),5'-bisphosphate nucleotidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014577.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W203, P32179, Q6RFY5
    UniProtKB/TrEMBL
    A6ZNE6, B3LIZ6, C7GK31, G2WMH0, N1NWD7
    Conserved Domains (1) summary
    TIGR01330
    Location:2 → 357
    bisphos_HAL2; 3'(2'),5'-bisphosphate nucleotidase, HAL2 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32179.1

Gene LinkOut

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