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THP1 Thp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854082, updated on 3-Nov-2024

Summary

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Official Symbol
THP1
Official Full Name
Thp1p
Primary source
SGD:S000005433
Locus tag
YOL072W
See related
AllianceGenome:SGD:S000005433; FungiDB:YOL072W; VEuPathDB:YOL072W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BUD29
Summary
Enables RNA binding activity and double-stranded DNA binding activity. Involved in several processes, including RNA metabolic process; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; and transcription-coupled nucleotide-excision repair. Located in nuclear envelope. Part of transcription export complex 2. Orthologous to human PCID2 (PCI domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See THP1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (194970..196337)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dsc2p Neighboring gene succinate dehydrogenase assembly factor SDH5 Neighboring gene Nba1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions. Santos-Pereira JM, et al. Nucleic Acids Res, 2014 Oct 29. PMID 25294824, Free PMC Article
  2. Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. Gallardo M, et al. J Biol Chem, 2003 Jun 27. PMID 12702719
  3. The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. Ciccarelli FD, et al. BMC Bioinformatics, 2003 Dec 19. PMID 14687415, Free PMC Article
  4. A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination. Gallardo M, et al. Genetics, 2001 Jan. PMID 11139493, Free PMC Article
  5. Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. Chekanova JA, et al. RNA, 2008 Jan. PMID 18003937, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thp1-Sac3-Sus1-Cdc31, together with THO/TREX, define a specific pathway connecting transcription elongation with export via an RNA-dependent dynamic process
    Title: The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular bud site selection HMP PubMed 
involved_in mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear mRNA surveillance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription-coupled nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription export complex 2 IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription export complex 2 IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Thp1p
NP_014569.1
  • Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    194970..196337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183327.1 → NP_014569.1  TPA: Thp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014569.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1Z5, Q08231
    UniProtKB/TrEMBL
    B5VRI1, C7GK39, N1P421
    Conserved Domains (1) summary
    COG5600
    Location:1 → 438
    COG5600; Transcription-associated recombination protein [DNA replication, recombination, and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08231.1

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