U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IZH4 Izh4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854052, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
IZH4
Official Full Name
Izh4p
Primary source
SGD:S000005461
Locus tag
YOL101C
See related
AllianceGenome:SGD:S000005461; FungiDB:YOL101C; VEuPathDB:YOL101C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable signaling receptor activity. Involved in intracellular zinc ion homeostasis. Located in fungal-type vacuole and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IZH4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (126982..127920, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene myo-inositol transporter ITR2 Neighboring gene tRNA 2'-phosphotransferase Neighboring gene serine/threonine protein kinase PKH2 Neighboring gene Sdd3p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets. Villa NY, et al. J Mol Evol, 2011 Oct. PMID 22009226, Free PMC Article
  2. Metalloregulation of yeast membrane steroid receptor homologs. Lyons TJ, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15060275, Free PMC Article
  3. Disruption of six novel genes from the left arm of chromosome XV of Saccharomyces cerevisiae and basic phenotypic analysis of the generated mutants. Séron K, et al. Yeast, 1999 Jan 15. PMID 10028187
  4. Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. Wendland B, et al. J Cell Biol, 1998 Apr 6. PMID 9531549, Free PMC Article
  5. A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin. McLaughlin JE, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 20007368, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Izh4p
NP_014540.1
  • Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    126982..127920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183355.1 → NP_014540.1  TPA: Izh4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014540.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1W7, Q6B2Z2, Q99393
    UniProtKB/TrEMBL
    A6ZNA8, B3LIW3, B5VRF4, C7GRV3, C8ZHL3, G2WMD4, N1NWB6
    Conserved Domains (1) summary
    cl03831
    Location:27 → 298
    HlyIII; Haemolysin-III related
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99393.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools