MSB4 Rab GTPase-activating protein MSB4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MSB4
Official Full Name: Rab GTPase-activating protein MSB4
Primary source: SGD:S000005472
Locus tag: YOL112W
See related: AllianceGenome:SGD:S000005472; FungiDB:YOL112W; VEuPathDB:YOL112W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GTPase activator activity. Involved in exocytosis and formin-nucleated actin cable assembly. Located in cellular bud tip; incipient cellular bud site; and mating projection tip. Part of polarisome. Used to study Ewing sarcoma. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Msb3 and Msb4 interact with Cdc42 and polarisome components to regulate cell polarity
Title: Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in formin-nucleated actin cable assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in formin-nucleated actin cable assembly	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of polarisome	IDA Inferred from Direct Assay more info	PubMed
located_in site of polarized growth	IEA Inferred from Electronic Annotation more info

NP_014529.1

GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant

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The following sections contain reference sequences that belong to a specific genome build. Explain