U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

VPS68 Vps68p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853991, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
VPS68
Official Full Name
Vps68p
Primary source
SGD:S000005489
Locus tag
YOL129W
See related
AllianceGenome:SGD:S000005489; FungiDB:YOL129W; VEuPathDB:YOL129W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in fungal-type vacuole membrane. Part of Vps55/Vps68 complex. Orthologous to several human genes including TMEM50B (transmembrane protein 50B). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See VPS68 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (77560..78114)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mg(2+) transporter ALR1 Neighboring gene serine/threonine protein kinase YGK3 Neighboring gene ribosomal 60S subunit protein L25

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Schluter C, et al. Mol Biol Cell, 2008 Apr. PMID 18216282, Free PMC Article
  2. Interaction between ESCRT-III proteins and the yeast SERINC homolog Tms1. Kölling R. Genetics, 2024 Oct 7. PMID 39271159
  3. Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae. Matsumoto R, et al. Protoplasma, 2013 Dec. PMID 23708375
  4. Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Bonangelino CJ, et al. Mol Biol Cell, 2002 Jul. PMID 12134085, Free PMC Article
  5. VID22 counteracts G-quadruplex-induced genome instability. Galati E, et al. Nucleic Acids Res, 2021 Dec 16. PMID 34871443, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking.
    Title: Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole HMP PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Vps55/Vps68 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Vps55/Vps68 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Vps55/Vps68 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Vps68p
NP_014512.1
  • Vacuolar membrane hypothetical protein; involved in vacuolar protein sorting; also detected in the mitochondria

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    77560..78114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183383.1 → NP_014512.1  TPA: Vps68p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014512.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1T9, Q12016
    UniProtKB/TrEMBL
    A6ZN82, B3LIT7, B5VRC9, C7GV05, C8ZHI7, G2WMA8, N1NWR6
    Conserved Domains (1) summary
    pfam05255
    Location:11 → 178
    UPF0220; Uncharacterized protein family (UPF0220)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12016.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools