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UBP11 ubiquitin-specific protease UBP11 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853973, updated on 2-Nov-2024

Summary

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Official Symbol
UBP11
Official Full Name
ubiquitin-specific protease UBP11
Primary source
SGD:S000001806
Locus tag
YKR098C
See related
AllianceGenome:SGD:S000001806; FungiDB:YKR098C; VEuPathDB:YKR098C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26) and USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See UBP11 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (633026..635179, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Esl2p Neighboring gene phosphoenolpyruvate carboxykinase PCK1 Neighboring gene Bas1p Neighboring gene Skg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome. Conan P, et al. Front Neurosci, 2022. PMID 36711154, Free PMC Article
  2. Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes. Layfield R, et al. Anal Biochem, 1999 Oct 1. PMID 10527495
  3. Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. Welsch CA, et al. J Biol Chem, 2003 Jul 18. PMID 12709439
  4. Autophagy as a Mechanism for Adaptive Prediction-Mediated Emergence of Drug Resistance. Nivedita N, et al. Front Microbiol, 2021. PMID 34566920, Free PMC Article
  5. Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae. Amerik AY, et al. Biol Chem, 2000 Sep-Oct. PMID 11076031

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-specific protease UBP11
NP_013024.1
  • Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    633026..635179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179888.1 → NP_013024.1  TPA: ubiquitin-specific protease UBP11 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013024.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXF9, P36026
    UniProtKB/TrEMBL
    B3LRH3, B5VMN9, C8ZCQ7
    Conserved Domains (1) summary
    pfam00443
    Location:298 → 704
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36026.1

Gene LinkOut

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