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TGL4 triacylglycerol lipase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853964, updated on 6-Oct-2024

Summary

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Official Symbol
TGL4
Official Full Name
triacylglycerol lipase
Primary source
SGD:S000001797
Locus tag
YKR089C
See related
AllianceGenome:SGD:S000001797; FungiDB:YKR089C; VEuPathDB:YKR089C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
STC1
Summary
Enables lipase activity and lysophosphatidic acid acyltransferase activity. Involved in cell budding; phospholipid metabolic process; and triglyceride metabolic process. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TGL4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (605633..608365, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene metalloendopeptidase Neighboring gene Tvp38p Neighboring gene Pxl1p Neighboring gene DNA-binding protein SRL3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae. Rajakumari S, et al. J Biol Chem, 2010 May 21. PMID 20332534, Free PMC Article
  2. Rapid triacylglycerol turnover in Chlamydomonas reinhardtii requires a lipase with broad substrate specificity. Li X, et al. Eukaryot Cell, 2012 Dec. PMID 23042128, Free PMC Article
  3. Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin. Low KL, et al. J Biol Chem, 2010 Jul 9. PMID 20452973, Free PMC Article
  4. Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. Athenstaedt K, et al. J Biol Chem, 2005 Nov 11. PMID 16135509
  5. Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast. Fang Z, et al. Acta Biol Hung, 2014 Dec. PMID 25475986

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae.
    Title: Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae.
  2. A genetically and functionally related network, consisting of components of the Rim101 pathway and the prefoldin, retromer and SWR1 complexes, and predict its functional relation to PLA(2) activity in a model eukaryotic cell.
    Title: Genetic interactions between a phospholipase A2 and the Rim101 pathway components in S. cerevisiae reveal a role for this pathway in response to changes in membrane composition and shape.
  3. The major yeast TG lipase Tgl4, the functional ortholog of murine adipose TG lipase ATGL, is phosphorylated and activated by cyclin-dependent kinase 1 (Cdk1/Cdc28).
    Title: Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression.
  4. The identification of Tgl4p and Tgl5p as additional TAG lipases of the yeast is reported.
    Title: Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles.
  5. yeast Tgl4 is a functional ortholog of mammalian adipose triglyceride lipase
    Title: Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-independent phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol ester esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol ester esterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables triacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell budding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell budding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride mobilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride mobilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lipid droplet HDA PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
triacylglycerol lipase
NP_013015.1
  • Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    605633..608365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179879.1 → NP_013015.1  TPA: triacylglycerol lipase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013015.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXE9, P36165
    UniProtKB/TrEMBL
    A7A048, B3LRG3, B5VMN1, C8ZCQ0, N1P105
    Conserved Domains (2) summary
    cd07230
    Location:210 → 632
    Pat_TGL4-5_like; Triacylglycerol lipase 4 and 5
    pfam11815
    Location:139 → 275
    DUF3336; Domain of unknown function (DUF3336)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36165.1

Gene LinkOut

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