BET3 TRAPP complex core subunit BET3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BET3
Official Full Name: TRAPP complex core subunit BET3
Primary source: SGD:S000001776
Locus tag: YKR068C
See related: AllianceGenome:SGD:S000001776; FungiDB:YKR068C; VEuPathDB:YKR068C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including Golgi vesicle transport; cellular response to nitrogen starvation; and cytoplasm to vacuole targeting by the Cvt pathway. Located in cis-Golgi network membrane. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Orthologous to several human genes including TRAPPC3 (trafficking protein particle complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BET3 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (570328..570909, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bet3 is involved in autophagy and participates in autophagy through TRAPP complexes mostly via Ypt1 in yeast.
Title: Bet3 participates in autophagy through GTPase Ypt1 in Saccharomyces cerevisiae.
Incorporated into the transport protein particle by Trs33.
Title: Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to guanyl-nucleotide exchange factor activity	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi vesicle transport	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitrogen starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasm to vacuole targeting by the Cvt pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intra-Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of TRAPP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAPP complex	IEA Inferred from Electronic Annotation more info
part_of TRAPPI protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPPII protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPPIII protein complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cis-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cis-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TRAPP complex core subunit BET3

NP_012994.1

Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

570328..570909 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179858.1 → NP_012994.1 TPA: TRAPP complex core subunit BET3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012994.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXC9, P36149

UniProtKB/TrEMBL

A7A028, B3LRE3, B5VML5, C7GX71, C8ZCN0, G2WI96, N1P0J3

Conserved Domains (1) summary

cd14942
Location:26 → 182

TRAPPC3_bet3; Bet3-TRAPPC3 subunit of the TRAPP complex