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LAS1 rRNA-processing protein LAS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853937, updated on 2-Nov-2024

Summary

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Official Symbol
LAS1
Official Full Name
rRNA-processing protein LAS1
Primary source
SGD:S000001771
Locus tag
YKR063C
See related
AllianceGenome:SGD:S000001771; FungiDB:YKR063C; VEuPathDB:YKR063C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endonuclease activity. Involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleolus. Part of preribosome, large subunit precursor. Used to study Wilson-Turner syndrome. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LAS1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (560789..562297, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene transcription factor TFIIE subunit TFA2 Neighboring gene Oaf3p Neighboring gene Pam17p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly. Pillon MC, et al. J Biol Chem, 2020 May 1. PMID 32220933, Free PMC Article
  2. Characterization of the molecular crosstalk within the essential Grc3/Las1 pre-rRNA processing complex. Pillon MC, et al. RNA, 2018 May. PMID 29440475, Free PMC Article
  3. Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage. Pillon MC, et al. Proc Natl Acad Sci U S A, 2017 Jul 11. PMID 28652339, Free PMC Article
  4. Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery. Chen J, et al. Elife, 2024 Jan 5. PMID 38180340, Free PMC Article
  5. LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth. Doseff AI, et al. Genetics, 1995 Nov. PMID 8582632, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5.8S rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Las1 complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
rRNA-processing protein LAS1
NP_012989.3
  • Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    560789..562297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179853.3 → NP_012989.3  TPA: rRNA-processing protein LAS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012989.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXC4, P36146, Q66R55
    UniProtKB/TrEMBL
    B5VML0, C8ZCM6, N1P0J1
    Conserved Domains (1) summary
    pfam04031
    Location:7 → 161
    Las1; Las1-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36146.1

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