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RHO4 Rho family GTPase RHO4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853929, updated on 2-Nov-2024

Summary

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Official Symbol
RHO4
Official Full Name
Rho family GTPase RHO4
Primary source
SGD:S000001763
Locus tag
YKR055W
See related
AllianceGenome:SGD:S000001763; FungiDB:YKR055W; VEuPathDB:YKR055W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity. Involved in maintenance of cell polarity and positive regulation of formin-nucleated actin cable assembly. Located in cellular bud neck; incipient cellular bud site; and plasma membrane. Orthologous to several human genes including RND1 (Rho family GTPase 1); RND2 (Rho family GTPase 2); and RND3 (Rho family GTPase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RHO4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (548216..549091)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene sphinganine kinase YSR3 Neighboring gene dynein heavy chain Neighboring gene tRNA (uracil(54)-C(5))-methyltransferase Neighboring gene ribosomal 40S subunit protein S21A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae. Matsui Y, et al. Gene, 1992 May 1. PMID 1587484
  2. The RHO4a and NUD1 genes on Saccharomyces cerevisiae chromosome XI. Van Vliet-Reedijk JC, et al. Yeast, 1993 Oct. PMID 8256523
  3. Genetic analysis of the Saccharomyces cerevisiae RHO3 gene, encoding a rho-type small GTPase, provides evidence for a role in bud formation. Imai J, et al. Genetics, 1996 Feb. PMID 8852836, Free PMC Article
  4. Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. Imamura H, et al. EMBO J, 1997 May 15. PMID 9184220, Free PMC Article
  5. The yeast Rgd1p is a GTPase activating protein of the Rho3 and rho4 proteins. Doignon F, et al. FEBS Lett, 1999 Oct 15. PMID 10526184

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bem2 might be a novel GTPase-activating protein for Rho4 in Saccharomyces cerevisiae.
    Title: Control of polarized growth by the Rho family GTPase Rho4 in budding yeast: requirement of the N-terminal extension of Rho4 and regulation by the Rho GTPase-activating protein Bem2.
  2. Wsc1p participates in the regulation of a Rho3/4-dependent cellular mechanism.
    Title: The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of formin-nucleated actin cable assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of formin-nucleated actin cable assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho family GTPase RHO4
NP_012981.3
  • Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    548216..549091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179845.3 → NP_012981.3  TPA: Rho family GTPase RHO4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012981.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXB6, P30618, Q00246
    UniProtKB/TrEMBL
    G2WI83, N1NZI1
    Conserved Domains (1) summary
    cd04132
    Location:70 → 248
    Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00246.2

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