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RSC4 Rsc4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853877, updated on 18-Sep-2024

Summary

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Official Symbol
RSC4
Official Full Name
Rsc4p
Primary source
SGD:S000001716
Locus tag
YKR008W
See related
AllianceGenome:SGD:S000001716; FungiDB:YKR008W; VEuPathDB:YKR008W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lysine-acetylated histone binding activity. Involved in nucleosome disassembly and transcription elongation from RNA polymerase II promoter. Part of RSC-type complex. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RSC4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (452201..454078)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL13 Neighboring gene Meh1p Neighboring gene bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of RSC58, which encodes a component of a yeast chromatin remodeling complex, and interacts with the transcription factor Swi6. Taneda T, et al. Mol Genet Genomics, 2004 May. PMID 15034784
  2. Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. VanDemark AP, et al. Mol Cell, 2007 Sep 7. PMID 17803945, Free PMC Article
  3. The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription. Mirón-García MC, et al. Nucleic Acids Res, 2014 Sep. PMID 25081216, Free PMC Article
  4. BAF180 promotes cohesion and prevents genome instability and aneuploidy. Brownlee PM, et al. Cell Rep, 2014 Mar 27. PMID 24613357, Free PMC Article
  5. Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Charles GM, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21673141, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. vital and yet redundant functions of histone H3 and Rsc4p acetylation in maintaining cell viability
    Title: Acetylation of Rsc4p by Gcn5p is essential in the absence of histone H3 acetylation.
  2. Rsc4 bears essential tandem bromodomains that rely on H3 Lys14 acetylation to assist RSC complex for gene activation
    Title: Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RSC-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RSC-type complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rsc4p
NP_012933.4
  • Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    452201..454078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179798.4 → NP_012933.4  TPA: Rsc4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012933.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX74, Q02206, Q6B1F7
    UniProtKB/TrEMBL
    B3LR92, C7GQG0, C8ZCH4, N1P0F9
    Conserved Domains (1) summary
    COG5076
    Location:40 → 423
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02206.2

Gene LinkOut

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