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ELM1 serine/threonine protein kinase ELM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853818, updated on 14-Nov-2024

Summary

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Official Symbol
ELM1
Official Full Name
serine/threonine protein kinase ELM1
Primary source
SGD:S000001531
Locus tag
YKL048C
See related
AllianceGenome:SGD:S000001531; FungiDB:YKL048C; VEuPathDB:YKL048C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LDB9
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including protein localization to septin ring; pseudohyphal growth; and septin ring assembly. Acts upstream of or within maltose metabolic process. Located in cellular bud neck septin ring. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ELM1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (347214..349136, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Lpx2p Neighboring gene centromeric DNA-binding histone H3-like protein CSE4 Neighboring gene Anr2p Neighboring gene putative mannan endo-1,6-alpha-mannosidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serine-threonine protein kinase activity of Elm1p, a regulator of morphologic differentiation in Saccharomyces cerevisiae. Koehler CM, et al. FEBS Lett, 1997 May 12. PMID 9180279
  2. Role of Elm1, Tos3, and Sak1 Protein Kinases in the Maltose Metabolism of Baker's Yeast. Yang X, et al. Front Microbiol, 2021. PMID 34140941, Free PMC Article
  3. Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit. Torres MP, et al. J Biol Chem, 2011 Jun 10. PMID 21521692, Free PMC Article
  4. Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling. Marquardt J, et al. J Cell Biol, 2024 May 6. PMID 38448162, Free PMC Article
  5. Mutational analysis of morphologic differentiation in Saccharomyces cerevisiae. Blacketer MJ, et al. Genetics, 1995 Aug. PMID 7498768, Free PMC Article

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
    Title: Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
  2. The LKB1-like Kinase Elm1 Controls Septin Hourglass Assembly and Stability by Regulating Filament Pairing.
    Title: The LKB1-like Kinase Elm1 Controls Septin Hourglass Assembly and Stability by Regulating Filament Pairing.
  3. Findings suggest that Elm1 plays a key role in sensing bud emergence.
    Title: Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.
  4. Dma1 and Dma2 control septin dynamics and the SPOC by promoting the efficient recruitment of Elm1 to the bud neck
    Title: Budding yeast dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the Elm1 kinase to the bud neck.
  5. Hsl1p activation involves the phosphorylation of threonine 273, promoted by the septin-associated kinase Elm1p.
    Title: The checkpoint kinase Hsl1p is activated by Elm1p-dependent phosphorylation.
  6. Elm1 regulates the septin assembly-dependent cellular events by directly phosphorylating and activating the Gin4-dependent pathway
    Title: Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast.
  7. ELM1, and genes encoding related serine/threonine protein kinases, are required for regulation of multidrug resistance involving, at least in part, control of PDR5 transcription.
    Title: ELM1 is required for multidrug resistance in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in budding cell bud growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within maltose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to septin ring IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck septin ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck septin ring IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine protein kinase ELM1
NP_012876.1
  • Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf1p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    347214..349136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179614.1 → NP_012876.1  TPA: serine/threonine protein kinase ELM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012876.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXN9, P32801
    UniProtKB/TrEMBL
    A6ZZR8, B3LR41, B5VMA9, C7GP26, N1NZ87
    Conserved Domains (1) summary
    cl21453
    Location:95 → 402
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32801.2

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