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SFK1 Sfk1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853815, updated on 2-Nov-2024

Summary

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Official Symbol
SFK1
Official Full Name
Sfk1p
Primary source
SGD:S000001534
Locus tag
YKL051W
See related
AllianceGenome:SGD:S000001534; FungiDB:YKL051W; VEuPathDB:YKL051W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in actin cytoskeleton organization; negative regulation of phospholipid translocation; and vacuole organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SFK1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (341312..342373)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mdm35p Neighboring gene Ask1p Neighboring gene Lpx2p Neighboring gene centromeric DNA-binding histone H3-like protein CSE4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. Butcher RA, et al. Chem Biol, 2003 Jun. PMID 12837385
  2. A heat-sensitive Osh protein controls PI4P polarity. Omnus DJ, et al. BMC Biol, 2020 Mar 13. PMID 32169085, Free PMC Article
  3. Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane. Kishimoto T, et al. Mol Biol Cell, 2021 Jul 15. PMID 34038161, Free PMC Article
  4. Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Audhya A, et al. Dev Cell, 2002 May. PMID 12015967
  5. Phospholipid flippases and Sfk1p, a novel regulator of phospholipid asymmetry, contribute to low permeability of the plasma membrane. Mioka T, et al. Mol Biol Cell, 2018 May 15. PMID 29540528, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane.
    Title: Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phospholipid translocation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Sfk1p
NP_012873.1
  • Protein that regulates phospholipid asymmetry at plasma membrane; may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    341312..342373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179617.1 → NP_012873.1  TPA: Sfk1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012873.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXN6, P35735
    UniProtKB/TrEMBL
    B3LR38, C7GP23, N1P7V7
    Conserved Domains (1) summary
    pfam10277
    Location:10 → 285
    Frag1; Frag1/DRAM/Sfk1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35735.1

Gene LinkOut

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