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ASK1 Ask1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853814, updated on 18-Sep-2024

Summary

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Official Symbol
ASK1
Official Full Name
Ask1p
Primary source
SGD:S000001535
Locus tag
YKL052C
See related
AllianceGenome:SGD:S000001535; FungiDB:YKL052C; VEuPathDB:YKL052C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to microtubule plus-end binding activity. Involved in positive regulation of attachment of spindle microtubules to kinetochore and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ASK1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (339668..340546, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1 Neighboring gene Mdm35p Neighboring gene Sfk1p Neighboring gene Lpx2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs. Thompson MK, et al. Elife, 2016 Apr 27. PMID 27117520, Free PMC Article
  2. The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae. Li Y, et al. Cell Cycle, 2003 Mar-Apr. PMID 12695666
  3. Three interacting regions of the Ndc80 and Dam1 complexes support microtubule tip-coupling under load. Flores RL, et al. J Cell Biol, 2022 May 2. PMID 35353161, Free PMC Article
  4. The Ndc80 complex bridges two Dam1 complex rings. Kim JO, et al. Elife, 2017 Feb 13. PMID 28191870, Free PMC Article
  5. Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes. Lampert F, et al. J Cell Biol, 2013 Jan 7. PMID 23277429, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
    Title: Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
  2. Together these results reveal a role for Asc1/RACK1 in a length-dependent initiation mechanism optimized for efficient translation of genes with important housekeeping functions.
    Title: The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs.
  3. Results describe two novel subunits of DASH, Hsk2 and Hsk3 (helper of Ask1), and suggest that Hsk3 acts to incorporate Ask1 into the DASH complex.
    Title: Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DASH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DASH complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitotic spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ask1p
NP_012872.2
  • Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    339668..340546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179618.1 → NP_012872.2  TPA: Ask1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012872.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXN5, P35734, Q68EC3, Q6B290
    UniProtKB/TrEMBL
    C7GP22, N1NZ83
    Conserved Domains (1) summary
    pfam08655
    Location:10 → 73
    DASH_Ask1; DASH complex subunit Ask1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35734.2

Gene LinkOut

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