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OAR1 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) [ Saccharomyces cerevisiae S288C ]

Gene ID: 853810, updated on 14-Nov-2024

Summary

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Official Symbol
OAR1
Official Full Name
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)
Primary source
SGD:S000001538
Locus tag
YKL055C
See related
AllianceGenome:SGD:S000001538; FungiDB:YKL055C; VEuPathDB:YKL055C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity. Involved in aerobic respiration and fatty acid metabolic process. Located in mitochondrion. Used to study mitochondrial metabolism disease. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See OAR1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (335321..336157, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Nup120p Neighboring gene Tma19p Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1 Neighboring gene Mdm35p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into cofactor recognition of yeast mitochondria 3-oxoacyl-ACP reductase OAR1. Zhang Y, et al. IUBMB Life, 2013 Feb. PMID 23300157
  2. Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae. Schneider R, et al. Curr Genet, 1997 Dec. PMID 9388293
  3. Identification of the Leishmania major proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as components of fatty acid synthase II. Gurvitz A. J Biomed Biotechnol, 2009. PMID 20145708, Free PMC Article
  4. Caenorhabditis elegans F09E10.3 encodes a putative 3-oxoacyl-thioester reductase of mitochondrial type 2 fatty acid synthase FASII that is functional in yeast. Gurvitz A. J Biomed Biotechnol, 2009. PMID 19746209, Free PMC Article
  5. The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2. Gurvitz A. Mol Genet Genomics, 2009 Oct. PMID 19685079, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ymtOAR1 forms a homodimer, and undergoes conformational changes upon NADPH binding to the active site.
    Title: Structural insights into cofactor recognition of yeast mitochondria 3-oxoacyl-ACP reductase OAR1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables quinone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)
NP_012868.1
  • Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    335321..336157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179621.2 → NP_012868.1  TPA: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXN2, P35731
    UniProtKB/TrEMBL
    B3LR36, B5VMA1, C7GP19, C8ZCB7, N1P0M1
    Conserved Domains (1) summary
    cd05233
    Location:7 → 275
    SDR_c; classical (c) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35731.1

Gene LinkOut

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