U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMA19 Tma19p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853809, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TMA19
Official Full Name
Tma19p
Primary source
SGD:S000001539
Locus tag
YKL056C
See related
AllianceGenome:SGD:S000001539; FungiDB:YKL056C; VEuPathDB:YKL056C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MMI1
Summary
Predicted to enable calcium ion binding activity. Involved in cytoplasmic translation and negative regulation of autophagy. Located in cytosol and mitochondrion. Orthologous to several human genes including TPT1P8 (TPT1 pseudogene 8) and TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TMA19 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (334412..334915, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIA subunit gamma Neighboring gene Nup120p Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activity. Rinnerthaler M, et al. PLoS One, 2013. PMID 24204967, Free PMC Article
  2. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Sanchez JC, et al. Electrophoresis, 1997 Jan. PMID 9059837
  3. S. cerevisiae Strain Lacking Mitochondrial IF3 Shows Increased Levels of Tma19p during Adaptation to Respiratory Growth. Levitskii S, et al. Cells, 2019 Jun 26. PMID 31248014, Free PMC Article
  4. Mmi1, the Yeast Ortholog of Mammalian Translationally Controlled Tumor Protein (TCTP), Negatively Affects Rapamycin-Induced Autophagy in Post-Diauxic Growth Phase. Vojtova J, et al. Cells, 2020 Jan 7. PMID 31936125, Free PMC Article
  5. Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae. Takahashi T, et al. J Toxicol Sci, 2010 Dec. PMID 21139346

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrates that in budding yeast Saccharomyces cerevisiae slow adaptation from glycolysis to respiration in the absence of mitochondrial translation initiation factor 3 (Aim23p) is accompanied by a gradual increase of cytochrome c oxidase activity and by increased levels of Tma19p protein, which protects mitochondria from oxidative stress.
    Title: S. cerevisiae Strain Lacking Mitochondrial IF3 Shows Increased Levels of Tma19p during Adaptation to Respiratory Growth.
  2. Mmi1p is one of the few proteins establishing a functional link between microtubules and mitochondria which may be needed for correct localization of mitochondria during cell division.
    Title: MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Tma19p
NP_012867.1
  • Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; homolog of human TPT1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    334412..334915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179622.1 → NP_012867.1  TPA: Tma19p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012867.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXN1, P35691
    UniProtKB/TrEMBL
    A6ZZR0, B3LR35, C7GP18, C8ZCB6, G2WHX6, N1P7V2
    Conserved Domains (1) summary
    pfam00838
    Location:1 → 161
    TCTP; Translationally controlled tumor protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35691.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools