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MSN4 stress-responsive transcriptional activator MSN4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853803, updated on 2-Nov-2024

Summary

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Official Symbol
MSN4
Official Full Name
stress-responsive transcriptional activator MSN4
Primary source
SGD:S000001545
Locus tag
YKL062W
See related
AllianceGenome:SGD:S000001545; FungiDB:YKL062W; VEuPathDB:YKL062W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to ethanol; cellular response to freezing; and cellular response to pH. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MSN4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (323228..325120)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative Mg(2+) transporter MNR2 Neighboring gene uncharacterized protein Neighboring gene Bli1p Neighboring gene fructose-bisphosphate aldolase FBA1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression profiling reveals an unexpected growth-stimulating effect of surplus iron on the yeast Saccharomyces cerevisiae. Du Y, et al. Mol Cells, 2012 Aug. PMID 22907175, Free PMC Article
  2. Enhancement of the initial rate of ethanol fermentation due to dysfunction of yeast stress response components Msn2p and/or Msn4p. Watanabe D, et al. Appl Environ Microbiol, 2011 Feb. PMID 21131516, Free PMC Article
  3. Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae. Jacquet M, et al. J Cell Biol, 2003 May 12. PMID 12732613, Free PMC Article
  4. Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans. Nicholls S, et al. Eukaryot Cell, 2004 Oct. PMID 15470239, Free PMC Article
  5. Cold adaptation in budding yeast. Schade B, et al. Mol Biol Cell, 2004 Dec. PMID 15483057, Free PMC Article

See all (245) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of the transcription factors Hsf1, Msn2 and Msn4 in yeast uncovers transcriptional reprogramming in response to proteotoxic stress.
    Title: Deletion of the transcription factors Hsf1, Msn2 and Msn4 in yeast uncovers transcriptional reprogramming in response to proteotoxic stress.
  2. Msn2/4 transcription factors positively regulate expression of Atg39 ER-phagy receptor.
    Title: Msn2/4 transcription factors positively regulate expression of Atg39 ER-phagy receptor.
  3. This work attempts to reveal the significance of specific serine residues of Msn2/4p, as possible targets of PKA, through substitution of these serine residues with alanine.
    Title: Specific serine residues of Msn2/4 are responsible for regulation of alcohol fermentation rates and ethanol resistance.
  4. Msn2 and Msn4 promote ATG8 expression downstream of the histone deacetylase complex (HDAC) subunit Ume6, a previously identified negative regulator of ATG8 expression.
    Title: Stress-response transcription factors Msn2 and Msn4 couple TORC2-Ypk1 signaling and mitochondrial respiration to ATG8 gene expression and autophagy.
  5. e transcription factors also play an important role in the exit of quiescence and regrowth. By studying Saccharomyces cerevisiae under a continuous, nutrient-limited condition, we found that Msn2 and Msn4 function as master regulators of glycolytic genes in the quiescent-like phase.
    Title: Stress response factors drive regrowth of quiescent cells.
  6. Thus Msn2/4 exhibit a dual role in activating carbohydrate metabolism genes and stress response genes.
    Title: Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth.
  7. Data suggest that promoters of most genes involved in biogenesis, function, and regulation of peroxisomes contain msn2- and msn4-binding sites; msn2 exhibits increased occupancy on promoters of beta-oxidation genes in glucose-depleted conditions; thus, msn2 and msn4 transcription factors activate expression of genes involved in fatty acid oxidation.
    Title: The stress-regulatory transcription factors Msn2 and Msn4 regulate fatty acid oxidation in budding yeast.
  8. Target genes of Msn2 and Msn4 with fast activation kinetics can be fully induced by either factor, behaving as an 'OR' gate. In contrast, target genes with slow activation kinetics behave as an 'AND' gate, requiring distinct contributions from both factors, upon transient stimulation.
    Title: Dynamic control of gene regulatory logic by seemingly redundant transcription factors.
  9. Study demonstrate that Rpa12p interacts with the transcription factor Msn4p and prevents its binding to the promoter of AYR1, a key enzyme involved in triacylglycerol biosynthesis and mobilization of nonpolar lipids. These results suggest that the deletion of RPA12 derepresses Msn4p, thus activating the transcription of AYR1, which leads to the accumulation of triacylglycerol in the rpa12D mutant.
    Title: The RNA polymerase I subunit Rpa12p interacts with the stress-responsive transcription factor Msn4p to regulate lipid metabolism in budding yeast.
  10. Cdc55 phosphatase is not involved in cytosolic stress signal perception but is involved in a specific intranuclear mechanism to regulate Msn2 and Msn4 nuclear accumulation and chromatin association under stress conditions.
    Title: Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular hypotonic response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to alkaline pH IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to amino acid starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to arsenic-containing substance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to cold IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to ethanol IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to freezing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to glucose starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to heat IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hydrogen peroxide IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hydrostatic pressure IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to nitrogen starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to nitrosative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to salt IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to zinc ion starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular stress response to acidic pH IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular stress response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
stress-responsive transcriptional activator MSN4
NP_012861.1
  • Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    323228..325120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179628.1 → NP_012861.1  TPA: stress-responsive transcriptional activator MSN4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012861.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXM5, P33749, P35726
    UniProtKB/TrEMBL
    A0A3G9D666, B3LR29, B5VM94, C7GP12, N1P090
    Conserved Domains (2) summary
    COG5048
    Location:57 → 622
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:575 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33749.1

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