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MNR2 putative Mg(2+) transporter MNR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853801, updated on 2-Nov-2024

Summary

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Official Symbol
MNR2
Official Full Name
putative Mg(2+) transporter MNR2
Primary source
SGD:S000001547
Locus tag
YKL064W
See related
AllianceGenome:SGD:S000001547; FungiDB:YKL064W; VEuPathDB:YKL064W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables magnesium ion transmembrane transporter activity. Involved in intracellular magnesium ion homeostasis. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MNR2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (317764..320673)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Dpc7p Neighboring gene Yet1p Neighboring gene uncharacterized protein Neighboring gene stress-responsive transcriptional activator MSN4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of microtubule dynamic instability by the carboxy-terminal tail of β-tubulin. Fees CP, et al. Life Sci Alliance, 2018 May. PMID 29963657, Free PMC Article
  2. Bovine pancreatic trypsin inhibitor is a new antifungal peptide that inhibits cellular magnesium uptake. Bleackley MR, et al. Mol Microbiol, 2014 Jun. PMID 24750237
  3. Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. MacDiarmid CW, et al. J Biol Chem, 1998 Jan 16. PMID 9430719
  4. Regulation of Alr1 Mg transporter activity by intracellular magnesium. Lim PH, et al. PLoS One, 2011. PMID 21738593, Free PMC Article
  5. MNR2 regulates intracellular magnesium storage in Saccharomyces cerevisiae. Pisat NP, et al. Genetics, 2009 Nov. PMID 19720860, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Mnr2 was localized to the vacuole membrane, implicating this organelle in Mg storage.
    Title: MNR2 regulates intracellular magnesium storage in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular magnesium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular magnesium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole-mitochondrion membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative Mg(2+) transporter MNR2
NP_012859.1
  • Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    317764..320673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179630.1 → NP_012859.1  TPA: putative Mg(2+) transporter MNR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012859.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXM3, P35724
    UniProtKB/TrEMBL
    B3LR27, C8ZCA8, G2WHW8, N1P0L0
    Conserved Domains (1) summary
    cd12829
    Location:500 → 965
    Alr1p-like; Saccharomyces cerevisiae Alr1p-like subfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35724.1

Gene LinkOut

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