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RPC25 DNA-directed RNA polymerase III subunit RPC25 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853713, updated on 2-Nov-2024

Summary

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Official Symbol
RPC25
Official Full Name
DNA-directed RNA polymerase III subunit RPC25
Primary source
SGD:S000001627
Locus tag
YKL144C
See related
AllianceGenome:SGD:S000001627; FungiDB:YKL144C; VEuPathDB:YKL144C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YKL1
Summary
Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Part of RNA polymerase III complex. Orthologous to human POLR3H (RNA polymerase III subunit H). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPC25 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (175843..176481, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Avt3p Neighboring gene proteasome regulatory particle base subunit RPT1 Neighboring gene Ltv1p Neighboring gene Mrp8p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C25, an essential RNA polymerase III subunit related to the RNA polymerase II subunit RPB7. Sadhale PP, et al. Mol Cell Biol, 1994 Sep. PMID 8065349, Free PMC Article
  2. Rpc25, a conserved RNA polymerase III subunit, is critical for transcription initiation. Zaros C, et al. Mol Microbiol, 2005 Jan. PMID 15612920
  3. Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes. Abraham PR, et al. Yeast, 1992 Mar. PMID 1574929
  4. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. Siaut M, et al. Mol Cell Biol, 2003 Jan. PMID 12482973, Free PMC Article
  5. Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model. Jasiak AJ, et al. Mol Cell, 2006 Jul 7. PMID 16818233

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure of subunit C25 is determined.
    Title: Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase III activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation at RNA polymerase III promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase III promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC25
NP_012778.1
  • RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    175843..176481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179710.1 → NP_012778.1  TPA: DNA-directed RNA polymerase III subunit RPC25 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012778.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX52, P35718
    UniProtKB/TrEMBL
    A6ZZH7, B3LQV6, C7GSN9, C8ZC31, G2WHP4, N1P2Y7
    Conserved Domains (1) summary
    TIGR00448
    Location:1 → 184
    rpoE; DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35718.1

Gene LinkOut

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