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ZRT3 Zn(2+) transporter ZRT3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853679, updated on 17-May-2024

Summary

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Gene symbol
ZRT3
Gene description
Zn(2+) transporter ZRT3
Primary source
FungiDB:YKL175W
Locus tag
YKL175W
See related
SGD:S000001658; AllianceGenome:SGD:S000001658; VEuPathDB:YKL175W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables zinc ion transmembrane transporter activity. Involved in cellular zinc ion homeostasis and zinc ion transport. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ZRT3 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (118793..120304)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ste3p Neighboring gene Lst4p Neighboring gene Tpo5p Neighboring gene U5 snRNP GTPase SNU114

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation. Yang X, et al. J Cell Biol, 2021 Aug 2. PMID 34047770, Free PMC Article
  2. Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. MacDiarmid CW, et al. EMBO J, 2000 Jun 15. PMID 10856230, Free PMC Article
  3. Proteomic and genetic analysis of the response of S. cerevisiae to soluble copper leads to improvement of the antimicrobial function of cellulosic copper nanoparticles. Rong-Mullins X, et al. Metallomics, 2017 Sep 20. PMID 28869270, Free PMC Article
  4. Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Lyons TJ, et al. Proc Natl Acad Sci U S A, 2000 Jul 5. PMID 10884426, Free PMC Article
  5. Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. Li M, et al. J Cell Biol, 2015 Nov 9. PMID 26527740, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zn(2+) transporter ZRT3
NP_012746.1
  • Vacuolar membrane zinc transporter; transports zinc from storage in vacuole to cytoplasm when needed; transcription induced under conditions of zinc deficiency; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    118793..120304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179741.1 → NP_012746.1  TPA: Zn(2+) transporter ZRT3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012746.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX25, P34240
    UniProtKB/TrEMBL
    A0A8H4FAC2, A6ZZF0, B3LQT0, C7GJ34, G2WHL7, N1P896
    Conserved Domains (2) summary
    COG0428
    Location:319 → 495
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    cl00437
    Location:8 → 93
    Zip; ZIP Zinc transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34240.2

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