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STE3 Ste3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853677, updated on 2-Nov-2024

Summary

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Official Symbol
STE3
Official Full Name
Ste3p
Primary source
SGD:S000001661
Locus tag
YKL178C
See related
AllianceGenome:SGD:S000001661; FungiDB:YKL178C; VEuPathDB:YKL178C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DAF2
Summary
Enables mating-type a-factor pheromone receptor activity. Involved in cytogamy and pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STE3 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (113215..114627, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L17A Neighboring gene Coy1p Neighboring gene Lst4p Neighboring gene Zn(2+) transporter ZRT3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitination of the yeast a-factor receptor. Roth AF, et al. J Cell Biol, 1996 Aug. PMID 8707846, Free PMC Article
  2. Induction of the yeast alpha-specific STE3 gene by the peptide pheromone a-factor. Hagen DC, et al. J Mol Biol, 1984 Oct 5. PMID 6436496
  3. Mutations that alter the third cytoplasmic loop of the a-factor receptor lead to a constitutive and hypersensitive phenotype. Boone C, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234336, Free PMC Article
  4. A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. Hsueh YP, et al. EMBO J, 2009 May 6. PMID 19322200, Free PMC Article
  5. Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. Hagen DC, et al. Proc Natl Acad Sci U S A, 1986 Mar. PMID 3006051, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The main difference between the Ste2 and Ste3 receptor observed in this work was that while hyperactive mutations were found for Ste3, no gain-of-function mutant for the Ste2 receptor was found. this fi nding is an outcome of the different strategies the two genes have adopted for their expression.
    Title: Analysis of random PCR-originated mutants of the yeast Ste2 and Ste3 receptors.
  2. no cryptic poly(A) sites are present in the a-factor receptor STE3 gene, indicating that S. cerevisiae has devised different strategies to regulate the two receptor genes STE2 and STE3
    Title: Yeast pheromone receptor genes STE2 and STE3 are differently regulated at the transcription and polyadenylation level.
  3. an interaction between Ste2p and Ste3p has roles in yeast cellular mating
    Title: A role for a complex between activated G protein-coupled receptors in yeast cellular mating.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables mating-type a-factor pheromone receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mating-type factor pheromone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mating-type factor pheromone receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cytogamy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ste3p
NP_012743.1
  • Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    113215..114627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179744.1 → NP_012743.1  TPA: Ste3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012743.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX23, P06783
    UniProtKB/TrEMBL
    A6ZZE8, B3LQS8, B5VLY6, C7GJ32, C8ZBZ7, G2WHL5, N1P0N0
    Conserved Domains (1) summary
    pfam02076
    Location:10 → 289
    STE3; Pheromone A receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06783.1

Gene LinkOut

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