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SRY1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853662, updated on 11-Sep-2024

Summary

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Official Symbol
SRY1
Primary source
SGD:S000001701
Locus tag
YKL218C
See related
AllianceGenome:SGD:S000001701; FungiDB:YKL218C; VEuPathDB:YKL218C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables threo-3-hydroxyaspartate ammonia-lyase activity. Involved in cellular modified amino acid catabolic process. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (17359..18339, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ferric/cupric-chelate reductase Neighboring gene Cos9p Neighboring gene monocarboxylate/H+ symporter Neighboring gene dihydroorotate dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serine racemase homologue of Saccharomyces cerevisiae has L-threo-3-hydroxyaspartate dehydratase activity. Wada M, et al. FEMS Microbiol Lett, 2003 Aug 29. PMID 12951240
  2. Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast. Ghosh C, et al. Sci Signal, 2021 May 25. PMID 34035143, Free PMC Article
  3. Snx4-assisted vacuolar targeting of transcription factors defines a new autophagy pathway for controlling ATG expression. Hanley SE, et al. Autophagy, 2021 Nov. PMID 33678121, Free PMC Article
  4. αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import. Ponce-Rojas JC, et al. FEBS J, 2017 Mar. PMID 28109174
  5. Systems-level effects of allosteric perturbations to a model molecular switch. Perica T, et al. Nature, 2021 Nov. PMID 34646016, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables serine racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threo-3-hydroxyaspartate ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables threo-3-hydroxyaspartate ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables threo-3-hydroxyaspartate ammonia-lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables threonine racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular modified amino acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular modified amino acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
threo-3-hydroxy-L-aspartate ammonia-lyase SRY1
NP_012704.1
  • 3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    17359..18339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179783.1 → NP_012704.1  TPA: threo-3-hydroxy-L-aspartate ammonia-lyase SRY1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012704.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWY5, P36007
    UniProtKB/TrEMBL
    A7A071, B3LQP1, G2WHH6, N1P2X9
    Conserved Domains (1) summary
    PRK07048
    Location:4 → 319
    PRK07048; threo-3-hydroxy-L-aspartate ammonia-lyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36007.1

Gene LinkOut

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