PXA2 ATP-binding cassette long-chain fatty acid transporter PXA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PXA2
Official Full Name: ATP-binding cassette long-chain fatty acid transporter PXA2
Primary source: SGD:S000001671
Locus tag: YKL188C
See related: AllianceGenome:SGD:S000001671; FungiDB:YKL188C; VEuPathDB:YKL188C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAT1
Summary: Enables ATPase-coupled transmembrane transporter activity. Involved in ATP transport and fatty acid transmembrane transport. Located in peroxisome. Is active in peroxisomal membrane. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ABCD1 (ATP binding cassette subfamily D member 1) and ABCD2 (ATP binding cassette subfamily D member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co-imports CoASH into the peroxisome.
Title: The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co-imports CoASH into the peroxisome.
The carboxyl-terminal region of Pxa2p is involved in its interaction with Pxa1p and in transporter function.
Title: Involvement of the carboxyl-terminal region of the yeast peroxisomal half ABC transporter Pxa2p in its interaction with Pxa1p and in transporter function.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid import into peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into peroxisome	IEA Inferred from Electronic Annotation more info
involved_in peroxisome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

Preferred Names: ATP-binding cassette long-chain fatty acid transporter PXA2

NP_012733.1

Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant

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The following sections contain reference sequences that belong to a specific genome build. Explain