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EAP1 Eap1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853631, updated on 18-Sep-2024

Summary

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Official Symbol
EAP1
Official Full Name
Eap1p
Primary source
SGD:S000001687
Locus tag
YKL204W
See related
AllianceGenome:SGD:S000001687; FungiDB:YKL204W; VEuPathDB:YKL204W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables eukaryotic initiation factor 4E binding activity. Involved in deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in cytoplasmic stress granule. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EAP1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (53704..55602)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Add66p Neighboring gene Ran GTPase-binding protein LOS1 Neighboring gene phosphatidylinositol kinase-related protein kinase TOR2 Neighboring gene Mnn4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of translation initiation by the yeast eIF4E binding proteins is required for the pseudohyphal response. Ibrahimo S, et al. Yeast, 2006 Oct-Nov. PMID 17083129
  2. The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation. Matsuo R, et al. FEBS Lett, 2005 Apr 25. PMID 15848184
  3. Genetic and biochemical interactions between SCP160 and EAP1 in yeast. Mendelsohn BA, et al. Nucleic Acids Res, 2003 Oct 15. PMID 14530432, Free PMC Article
  4. Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Cosentino GP, et al. Mol Cell Biol, 2000 Jul. PMID 10848587, Free PMC Article
  5. The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay. Rendl LM, et al. PLoS One, 2012. PMID 23071728, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The eIF4E-binding protein Eap1 has similar but independent roles in cell growth and gene expression with the cytoplasmic deadenylase Ccr4.
    Title: The eIF4E-binding protein Eap1 has similar but independent roles in cell growth and gene expression with the cytoplasmic deadenylase Ccr4.
  2. Crystal structures of the yeast eIF4E bound to Eap1p were determined.The canonical and non-canonical motifs in 4E-BPs and eIF4G contribute differently to the affinity for eIF4E.
    Title: Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
  3. the interaction of Vts1p with Eap1p at target mRNAs stimulates decapping and transcript decay
    Title: The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay.
  4. SESA network comprising Smy2, Eap1, Scp160 and Asc1 , specifically inhibits initiation of translation of POM34 mRNA that encodes an integral membrane protein of the nuclear pore complex
    Title: The SESA network links duplication of the yeast centrosome with the protein translation machinery.
  5. upon TOR-inactivation, the putative TOR-regulated eIF4E-associated protein Eap1p likely functions downstream of Gcn2p to attenuate GCN4 translation via a mechanism independent of eIF4E-binding
    Title: The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor 4E binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Eap1p
NP_012718.1
  • eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    53704..55602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179769.1 → NP_012718.1  TPA: Eap1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012718.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWZ9, P36041
    UniProtKB/TrEMBL
    B3LQQ5, B5VLW2, C8ZBX5, G2WHJ0, N1P0E6
    Conserved Domains (1) summary
    TIGR01628
    Location:555 → 622
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36041.1

Gene LinkOut

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