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NNF1 MIND complex subunit NNF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853576, updated on 2-Nov-2024

Summary

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Official Symbol
NNF1
Official Full Name
MIND complex subunit NNF1
Primary source
SGD:S000003873
Locus tag
YJR112W
See related
AllianceGenome:SGD:S000003873; FungiDB:YJR112W; VEuPathDB:YJR112W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in chromosome segregation. Located in kinetochore. Part of MIS12/MIND type complex. Human ortholog(s) of this gene implicated in bladder carcinoma and urinary bladder cancer. Orthologous to human PMF1-BGLAP (PMF1-BGLAP readthrough) and PMF1 (polyamine modulated factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NNF1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (637030..637635)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3-phosphatase YMR1 Neighboring gene Pxp2p Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein RSM7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NNF1 is an essential yeast gene required for proper spindle orientation, nucleolar and nuclear envelope structure and mRNA export. Shan X, et al. J Cell Sci, 1997 Jul. PMID 9247195
  2. Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. Scharfenberger M, et al. EMBO J, 2003 Dec 15. PMID 14657030, Free PMC Article
  3. The MEN mediates the effects of the spindle assembly checkpoint on Kar9-dependent spindle pole body inheritance in budding yeast. Hotz M, et al. Cell Cycle, 2012 Aug 15. PMID 22871738, Free PMC Article
  4. Regulation of mitotic spindle asymmetry by SUMO and the spindle-assembly checkpoint in yeast. Leisner C, et al. Curr Biol, 2008 Aug 26. PMID 18722122
  5. Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Dimitrova YN, et al. Cell, 2016 Nov 3. PMID 27881300, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MIS12/MIND type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MIS12/MIND type complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MIND complex subunit NNF1
NP_012646.3
  • Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for kinetochore bi-orientation and accurate chromosome segregation; complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; homologous to metazoan CENP-H proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    637030..637635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181770.3 → NP_012646.3  TPA: MIND complex subunit NNF1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012646.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWT1, P47149, Q06779
    UniProtKB/TrEMBL
    A6ZQ68, B3LQJ6, B5VLQ6, C7GM97, C8ZBR0, G2WHB5, N1P3N1
    Conserved Domains (1) summary
    pfam03980
    Location:49 → 155
    Nnf1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47149.3

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