U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IME1 transcription factor IME1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853556, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
IME1
Official Full Name
transcription factor IME1
Primary source
SGD:S000003854
Locus tag
YJR094C
See related
AllianceGenome:SGD:S000003854; FungiDB:YJR094C; VEuPathDB:YJR094C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in several processes, including positive regulation of transcription by RNA polymerase II; pseudohyphal growth; and regulation of meiotic nuclear division. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IME1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (604569..605651, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Bud4p Neighboring gene cleavage polyadenylation factor subunit FIP1 Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L43B

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Post-transcriptional regulation of IME1 determines initiation of meiosis in Saccharomyces cerevisiae. Sherman A, et al. Mol Gen Genet, 1993 Mar. PMID 8483452
  2. IME1 gene encodes a transcription factor which is required to induce meiosis in Saccharomyces cerevisiae. Mandel S, et al. Dev Genet, 1994. PMID 8205723
  3. A long region upstream of the IME1 gene regulates meiosis in yeast. Granot D, et al. Mol Gen Genet, 1989 Aug. PMID 2674657
  4. Transcription levels of a noncoding RNA orchestrate opposing regulatory and cell fate outcomes in yeast. Moretto F, et al. Cell Rep, 2021 Jan 19. PMID 33472063, Free PMC Article
  5. IME1, a positive regulator gene of meiosis in S. cerevisiae. Kassir Y, et al. Cell, 1988 Mar 25. PMID 3280136

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IME1 expression is regulated by upstream activation signals which reside within the IME1 promoter.
    Title: Multiple MAPK cascades regulate the transcription of IME1, the master transcriptional activator of meiosis in Saccharomyces cerevisiae.
  2. Epistasis analysis suggests that Ime1 and Ime2 act in the same order in pseudohyphal growth as in meiosis.
    Title: Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources.
  3. study shows that natural variation in sporulation efficiency between oak tree & vineyard strains is due to allelic variation between four nucleotide changes in three transcription factors: IME1, RME1 & RSF1
    Title: Genetic interactions between transcription factors cause natural variation in yeast.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor IME1
NP_012627.1
  • Master regulator of meiosis that is active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; regulator of meiotic commitment; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    604569..605651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181751.1 → NP_012627.1  TPA: transcription factor IME1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012627.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWR2, P21190
    UniProtKB/TrEMBL
    B8XW29, C7GMB3, E9P9J2, G2WH96, N1P1P3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21190.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools