GRR1 SCF ubiquitin ligase complex subunit GRR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GRR1
Official Full Name: SCF ubiquitin ligase complex subunit GRR1
Primary source: SGD:S000003850
Locus tag: YJR090C
See related: AllianceGenome:SGD:S000003850; FungiDB:YJR090C; VEuPathDB:YJR090C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CAT80; COT2; RMR3; SDC1; SSU2
Summary: Enables protein-macromolecule adaptor activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to methylmercury; and mitotic cell cycle G1 arrest in response to pheromone. Located in cellular bud neck contractile ring and nucleus. Part of SCF ubiquitin ligase complex. Orthologous to human FBXL13 (F-box and leucine rich repeat protein 13) and FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GRR1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (590872..594327, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We find that Ndd1 turnover in metaphase requires Cdk1 activity and the ubiquitin ligase SCF(Grr1).
Title: Ndd1 turnover by SCF(Grr1) is inhibited by the DNA damage checkpoint in Saccharomyces cerevisiae.
Data indicate that the degradation of She3 by Grr1 is required for optimal cell growth.
Title: Identification of She3 as an SCF(Grr1) substrate in budding yeast.
we show that Cln3 is redundantly targeted by two F-box proteins with key cell cycle-regulatory roles, Cdc4 and Grr1
Title: F-box protein specificity for g1 cyclins is dictated by subcellular localization.
Data indicate that Npr2, a homolog of human NPRL2, is a phosphorylation-dependent target of the SCF(Grr1) E3 ubiquitin ligase that plays a role in cell growth on some nitrogen sources.
Title: Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources.
A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.
Title: A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.
required for pheromone sensitivity
Title: The ubiquitin ligase SCFGrr1 is necessary for pheromone sensitivity in Saccharomyces cerevisiae.
In this study, we show that the other components of SCF(Grr1), including Skp1, Rbx1p, and the ubiquitin-conjugating enzyme Cdc34, are also necessary for glucose-induced Gal2p degradation.
Title: The ubiquitin ligase SCF(Grr1) is required for Gal2p degradation in the yeast Saccharomyces cerevisiae.
SCFGrr1p-dependent destruction of Ime2p kinase has a role in glucose inhibition of meiotic DNA replication
Title: Glucose inhibits meiotic DNA replication through SCFGrr1p-dependent destruction of Ime2p kinase.
Data suggest that casein kinase I plays a role in fungal nutritional signaling pathways by phosphorylating pathway components and targeting them for ubiquitination by SCFGrr1.
Title: Regulation and recognition of SCFGrr1 targets in the glucose and amino acid signaling pathways.
Grr1p plays an important role in the regulatory pathways that ultimately lead to transcriptional regulation by each of the components Mig1p and Rgt1p.
Title: Elucidation of the role of Grr1p in glucose sensing by Saccharomyces cerevisiae through genome-wide transcription analysis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in cellular response to methylmercury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle G1 arrest in response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cellular bud neck contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SCF ubiquitin ligase complex subunit GRR1

NP_012623.1

F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

590872..594327 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181747.1 → NP_012623.1 TPA: SCF ubiquitin ligase complex subunit GRR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012623.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWQ8, P24814

UniProtKB/TrEMBL

C7GMB7

Conserved Domains (3) summary

cd09293
Location:574 → 737

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:416 → 441

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:320 → 361

F-box-like