BIR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BIR1
Primary source: SGD:S000003849
Locus tag: YJR089W
See related: AllianceGenome:SGD:S000003849; FungiDB:YJR089W; VEuPathDB:YJR089W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable metal ion binding activity. Involved in several processes, including mitotic spindle assembly checkpoint signaling; septin cytoskeleton organization; and sister chromatid segregation. Located in several cellular components, including kinetochore; nucleus; and spindle midzone. Part of chromosome passenger complex. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (587718..590582)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
Title: SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
Results show that Bir1 is needed to permit efficient chromosome biorientation.
Title: Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1.
The establishment of tension removes Ipl1, Bir1, and Sli15, and their kinetochore detachment activity, from the vicinity of kinetochores and allows cells to proceed through the tension checkpoint.
Title: Bir1 is required for the tension checkpoint.
The interaction between Bir1p and Sli15p is specifically involved in regulating septin dynamics during anaphase.
Title: A Bir1p Sli15p kinetochore passenger complex regulates septin organization during anaphase.
Phosphorylation of the middle region of Bir1 is required to bring Ndc10 to the spindle at anaphase, which is required for full spindle elongation.
Title: Phosphorylation of the chromosomal passenger protein Bir1 is required for localization of Ndc10 to the spindle during anaphase and full spindle elongation.
Using an in vitro approach based on the sequence-specific budding yeast centromere, a complex of the chromosomal passenger proteins Bir1 and Sli15 (Survivin and INCENP) that links centromeres to microtubules was identified.
Title: A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension.
Data show that Bir1p is a substrate for Nma111p, which is the homologue of the human pro-apoptotic serine protease Omi/HtrA2 and which is known to mediate apoptosis in yeast.
Title: The inhibitor-of-apoptosis protein Bir1p protects against apoptosis in S. cerevisiae and is a substrate for the yeast homologue of Omi/HtrA2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid biorientation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromosome passenger complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IGI Inferred from Genetic Interaction more info	PubMed
located_in microtubule	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: survivin

NP_012622.3

Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

587718..590582

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181746.3 → NP_012622.3 TPA: survivin [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012622.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWQ7, P47134

UniProtKB/TrEMBL

C7GMB8

Conserved Domains (2) summary

smart00238
Location:151 → 241

BIR; Baculoviral inhibition of apoptosis protein repeat

cl00035
Location:18 → 76

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...