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MOG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853537, updated on 11-Sep-2024

Summary

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Official Symbol
MOG1
Primary source
SGD:S000003835
Locus tag
YJR074W
See related
AllianceGenome:SGD:S000003835; FungiDB:YJR074W; VEuPathDB:YJR074W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables small GTPase binding activity. Involved in protein import into nucleus. Located in nucleus. Orthologous to human RANGRF (RAN guanine nucleotide release factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (573095..573751)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene GTPase NPA3 Neighboring gene bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Neighboring gene alpha-1,6-mannosyltransferase Neighboring gene septin CDC11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of the PsbP protein of photosystem II from Nicotiana tabacum. Ifuku K, et al. EMBO Rep, 2004 Apr. PMID 15031714, Free PMC Article
  2. 1.9 A resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p. Stewart M, et al. J Mol Biol, 2000 May 26. PMID 10860733
  3. Crystallization and preliminary X-ray diffraction analysis of the Saccharomyces cerevisiae ran-binding protein Mog1p. Baker RP, et al. Acta Crystallogr D Biol Crystallogr, 2000 Feb. PMID 10666614
  4. Fission yeast Mog1p homologue, which interacts with the small GTPase Ran, is required for mitosis-to-interphase transition and poly(A)(+) RNA metabolism. Tatebayashi K, et al. Genetics, 2001 Apr. PMID 11290708, Free PMC Article
  5. Yrb1p interaction with the gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p. Oki M, et al. J Biol Chem, 2000 Oct 20. PMID 10921930

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ran GTPase-binding protein MOG1
NP_012608.1
  • Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    573095..573751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181732.1 → NP_012608.1  TPA: Ran GTPase-binding protein MOG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWP4, P47123
    UniProtKB/TrEMBL
    B5VLM6, G2WH78, N1P3I6
    Conserved Domains (1) summary
    cd00224
    Location:36 → 218
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47123.1

Gene LinkOut

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