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VPS55 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853502, updated on 11-Sep-2024

Summary

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Official Symbol
VPS55
Primary source
SGD:S000003805
Locus tag
YJR044C
See related
AllianceGenome:SGD:S000003805; FungiDB:YJR044C; VEuPathDB:YJR044C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in late endosome. Part of Vps55/Vps68 complex. Orthologous to human LEPROT (leptin receptor overlapping transcript) and LEPROTL1 (leptin receptor overlapping transcript like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (518763..519185, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta subunit POL32 Neighboring gene tRNA-Met Neighboring gene Hsp70 family ATPase SSC1 Neighboring gene Tah11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking. Belgareh-Touzé N, et al. Mol Biol Cell, 2002 May. PMID 12006663, Free PMC Article
  2. Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants. Avaro S, et al. Yeast, 2002 Mar 15. PMID 11870858
  3. Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Schluter C, et al. Mol Biol Cell, 2008 Apr. PMID 18216282, Free PMC Article
  4. A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling. Suzuki SW, et al. Elife, 2021 Sep 15. PMID 34524084, Free PMC Article
  5. Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae. Hedman JM, et al. Cell Biol Int, 2007 Oct. PMID 17543551

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking.
    Title: Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Vps55/Vps68 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Vps55/Vps68 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Vps55/Vps68 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vps55p
NP_012578.3
  • Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    518763..519185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181702.3 → NP_012578.3  TPA: Vps55p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012578.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWL5, P47111
    UniProtKB/TrEMBL
    A6ZQ03, B3LQD3, C7GTC4, D3UF93, G2WH48, N1P8P3
    Conserved Domains (1) summary
    pfam04133
    Location:12 → 131
    Vps55; Vacuolar protein sorting 55
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47111.1

Gene LinkOut

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