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LSM8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853479, updated on 11-Sep-2024

Summary

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Official Symbol
LSM8
Primary source
SGD:S000003783
Locus tag
YJR022W
See related
AllianceGenome:SGD:S000003783; FungiDB:YJR022W; VEuPathDB:YJR022W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleolus. Part of U4/U6 x U5 tri-snRNP complex and U6 snRNP. Orthologous to human LSM8 (LSM8 homolog, U6 small nuclear RNA associated). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (469784..470113)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene palmitoyl-CoA hydrolase Neighboring gene Rec107p Neighboring gene methylthioribulose 1-phosphate dehydratase MDE1 Neighboring gene 3-hydroxyanthranilate 3,4-dioxygenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast. Reijns MA, et al. FEBS J, 2009 Jul. PMID 19490016, Free PMC Article
  2. A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts. Pannone BK, et al. EMBO J, 1998 Dec 15. PMID 9857199, Free PMC Article
  3. An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors. Kucera NJ, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21212361, Free PMC Article
  4. Rapid isolation and single-molecule analysis of ribonucleoproteins from cell lysate by SNAP-SiMPull. Rodgers ML, et al. RNA, 2015 May. PMID 25805862, Free PMC Article
  5. Characterization of U6 snRNA-protein interactions. Vidal VP, et al. RNA, 1999 Nov. PMID 10580475, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe a range of mutant and hybrid Lsm1 and Lsm8 proteins, shedding light on the relative importance of their various domains in determining their localization and ability to support growth.
    Title: Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast.
  2. Lsm2-8p complex normally targets nuclear RNA substrates for decapping
    Title: Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U6 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U6 snRNP IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit LSM8
NP_012556.2
  • Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    469784..470113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181680.1 → NP_012556.2  TPA: U4/U6-U5 snRNP complex subunit LSM8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012556.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWJ6, P47093
    UniProtKB/TrEMBL
    A6ZPY8, B3LQB8, C7GWK9, D3UF83, G2WH33
    Conserved Domains (1) summary
    cd01727
    Location:2 → 85
    LSm8; Like-Sm protein 8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47093.2

Gene LinkOut

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