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SPC1 signal peptidase complex subunit SPC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853467, updated on 2-Nov-2024

Summary

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Official Symbol
SPC1
Official Full Name
signal peptidase complex subunit SPC1
Primary source
SGD:S000003770
Locus tag
YJR010C-A
See related
AllianceGenome:SGD:S000003770; FungiDB:YJR010C-A; VEuPathDB:YJR010C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein targeting to ER and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SPC1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (458077..458361, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Neighboring gene sulfate adenylyltransferase Neighboring gene Cal4p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spc1 regulates the signal peptidase-mediated processing of membrane proteins. Yim C, et al. J Cell Sci, 2021 Jul 1. PMID 34125229, Free PMC Article
  2. The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae. Fang H, et al. J Biol Chem, 1996 Jul 12. PMID 8663399
  3. Yeast signal peptidase contains a glycoprotein and the Sec11 gene product. YaDeau JT, et al. Proc Natl Acad Sci U S A, 1991 Jan 15. PMID 1846444, Free PMC Article
  4. Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. Mullins C, et al. J Biol Chem, 1996 Nov 15. PMID 8910564
  5. In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum. Fang H, et al. J Biol Chem, 1997 May 16. PMID 9148930

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spc1 regulates the signal peptidase-mediated processing of membrane proteins.
    Title: Spc1 regulates the signal peptidase-mediated processing of membrane proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to ER IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein targeting to ER IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
involved_in signal peptide processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal peptide processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
signal peptidase complex subunit SPC1
NP_012544.1
  • Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); regulates cellular levels of membrane proteins; homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    458077..458361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181667.1 → NP_012544.1  TPA: signal peptidase complex subunit SPC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012544.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWI6, P46965
    UniProtKB/TrEMBL
    A6ZPX8, B3LQB0, C7GWK1, C8ZBG6, G2WH22, N1P109
    Conserved Domains (1) summary
    pfam06645
    Location:16 → 85
    SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46965.1

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