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MET3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853466, updated on 11-Sep-2024

Summary

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Official Symbol
MET3
Primary source
SGD:S000003771
Locus tag
YJR010W
See related
AllianceGenome:SGD:S000003771; FungiDB:YJR010W; VEuPathDB:YJR010W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sulfate adenylyltransferase (ATP) activity. Involved in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) and sulfur amino acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) and PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (456239..457774)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mho1p Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Neighboring gene signal peptidase complex subunit SPC1 Neighboring gene Cal4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional analysis of a truncated form of Saccharomyces cerevisiae ATP sulfurylase: C-terminal domain essential for oligomer formation but not for activity. Lalor DJ, et al. Protein Eng, 2003 Dec. PMID 14983089
  2. Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant. Yang Z, et al. Microbiology (Reading), 2002 Aug. PMID 12177356
  3. Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation. Ullrich TC, et al. EMBO J, 2001 Feb 1. PMID 11157739, Free PMC Article
  4. Production, purification, and luminometric analysis of recombinant Saccharomyces cerevisiae MET3 adenosine triphosphate sulfurylase expressed in Escherichia coli. Karamohamed S, et al. Protein Expr Purif, 1999 Apr. PMID 10092498
  5. Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae. Cherest H, et al. J Bacteriol, 1969 Jan. PMID 5764336, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate adenylyltransferase (ATP) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate adenylyltransferase (ATP) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfate adenylyltransferase (ATP) activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate adenylyltransferase (ATP) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in hydrogen sulfide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation via adenylyl sulfate reduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
sulfate adenylyltransferase
NP_012543.3
  • ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    456239..457774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181668.3 → NP_012543.3  TPA: sulfate adenylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012543.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWI5, P08536, Q66R66
    UniProtKB/TrEMBL
    A6ZPX7, B3LQA9, C7GWK0, D3UF76, N1P8M1
    Conserved Domains (1) summary
    TIGR00339
    Location:4 → 386
    sopT; ATP sulphurylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08536.2

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