AIM22 putative lipoate--protein ligase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: AIM22
Official Full Name: putative lipoate--protein ligase
Primary source: SGD:S000003582
Locus tag: YJL046W
See related: AllianceGenome:SGD:S000003582; FungiDB:YJL046W; VEuPathDB:YJL046W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LIP3; RRG3
Summary: Predicted to enable lipoate-protein ligase activity and lipoyltransferase activity. Involved in protein lipoylation. Located in mitochondrion. Used to study Leigh disease. Orthologous to human LIPT1 (lipoyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AIM22 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (352386..353615)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Lip3 Lpl homologue of the yeast S. cerevisiae has octanoyl-CoA-protein transferase
Title: The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables lipoate-protein ligase activity	IEA Inferred from Electronic Annotation more info
enables lipoate-protein ligase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables lipoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein lipoylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative lipoate--protein ligase

NP_012489.2

EC 6.3.1.20

Lipoate-protein ligase; octanoyl-CoA: protein transferase required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

352386..353615

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181479.1 → NP_012489.2 TPA: putative lipoate--protein ligase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012489.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B3LQ66, B5VLD2, D6VWD8, P47051

UniProtKB/TrEMBL

C7GSU4, C8ZBG9, G2WGX2

Conserved Domains (1) summary

cl14057
Location:117 → 409

BPL_LplA_LipB; biotin-lipoate ligase family