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RTT101 cullin RTT101 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853400, updated on 2-Nov-2024

Summary

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Official Symbol
RTT101
Official Full Name
cullin RTT101
Primary source
SGD:S000003583
Locus tag
YJL047C
See related
AllianceGenome:SGD:S000003583; FungiDB:YJL047C; VEuPathDB:YJL047C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CUL8
Summary
Enables ubiquitin-protein transferase activity. Involved in several processes, including nonfunctional rRNA decay; regulation of mitotic nuclear division; and replication fork processing. Located in cytoplasm and nucleus. Part of Cul8-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RTT101 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (349580..352108, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Ubx6p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene putative lipoate--protein ligase Neighboring gene tRNA-Tyr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites. Luke B, et al. Curr Biol, 2006 Apr 18. PMID 16631586
  2. Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II. Baldwin EL, et al. Nucleic Acids Res, 2005. PMID 15718301, Free PMC Article
  3. The cullin Rtt101 promotes ubiquitin-dependent DNA-protein crosslink repair across the cell cycle. Noireterre A, et al. Nucleic Acids Res, 2024 Sep 9. PMID 39077933, Free PMC Article
  4. Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. Laplaza JM, et al. Biochem J, 2004 Jan 15. PMID 14519104, Free PMC Article
  5. Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system. Suter B, et al. Genome Res, 2007 Dec. PMID 17989249, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cullin Rtt101 promotes ubiquitin-dependent DNA-protein crosslink repair across the cell cycle.
    Title: The cullin Rtt101 promotes ubiquitin-dependent DNA-protein crosslink repair across the cell cycle.
  2. CAF-1 and Rtt101p function within the replication-coupled chromatin assembly network to promote H4 K16ac, preventing ectopic silencing.
    Title: CAF-1 and Rtt101p function within the replication-coupled chromatin assembly network to promote H4 K16ac, preventing ectopic silencing.
  3. These results indicate that both yeast Rtt101Mms1 and human Cul4ADDB1 are required for efficient deposition of new H3 onto DNA.
    Title: A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.
  4. These findings identify Spt16 as an Rtt101 substrate, and suggest that Spt16 ubiquitylation is important for FACT to function during DNA replication.
    Title: Ubiquitylation of FACT by the cullin-E3 ligase Rtt101 connects FACT to DNA replication.
  5. Cul8-Mms1, as part of various protein complexes, is involved in the regulation of chromatin metabolism
    Title: Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing.
  6. Rtt101(Mms1) ubiquitin ligase complex might be required to reorganize replication forks that encounter DNA lesions.
    Title: Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA.
  7. These results indicate that Rtt109, Rtt101, and Rtt107, which genetic evidence suggests are functionally related, form a DNA damage response pathway that recruits Rtt107 complexes to damaged or stalled replication forks.
    Title: Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nonfunctional rRNA decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul8-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cullin RTT101
NP_012488.3
  • Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    349580..352108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181480.3 → NP_012488.3  TPA: cullin RTT101 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012488.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWD7, P47050
    UniProtKB/TrEMBL
    A6ZPT0, B3LQ65, C8ZBB4, G2WGX1, N1P8I6
    Conserved Domains (1) summary
    COG5647
    Location:519 → 842
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47050.1

Gene LinkOut

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