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LAS21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853384, updated on 11-Sep-2024

Summary

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Official Symbol
LAS21
Primary source
SGD:S000003598
Locus tag
YJL062W
See related
AllianceGenome:SGD:S000003598; FungiDB:YJL062W; VEuPathDB:YJL062W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GPI7
Summary
Enables CP2 mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Is integral component of endoplasmic reticulum membrane and integral component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGG (phosphatidylinositol glycan anchor biosynthesis class G). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (317284..319776)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL8 Neighboring gene Coa3p Neighboring gene linker nucleoporin NUP82 Neighboring gene kynurenine--oxoglutarate transaminase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GPI7 affects cell-wall protein anchorage in Saccharomyces cerevisiae and Candida albicans. Richard M, et al. Microbiology (Reading), 2002 Jul. PMID 12101300
  2. Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. Benachour A, et al. J Biol Chem, 1999 May 21. PMID 10329735
  3. COPII coat composition is actively regulated by luminal cargo maturation. Manzano-Lopez J, et al. Curr Biol, 2015 Jan 19. PMID 25557665
  4. [Biosynthetic pathway of GPI-anchored cell wall mannoproteins in yeast as a potential target for anti-fungal and anti-cancer drugs]. Jigami Y. Nihon Ishinkin Gakkai Zasshi, 2008. PMID 19001750
  5. YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast. Flury I, et al. J Biol Chem, 2000 Aug 11. PMID 10823837

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. isolated gpi7 mutants, which have defects in cell separation and a daughter cell-specific growth defect at the non-permissive temperature
    Title: GPI7 involved in glycosylphosphatidylinositol biosynthesis is essential for yeast cell separation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables CP2 mannose-ethanolamine phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CP2 mannose-ethanolamine phosphotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannose-ethanolamine phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organophosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mannose-ethanolamine phosphotransferase LAS21
NP_012473.1
  • Mannose-ethanolamine phosphotransferase; involved in biosynthesis of the glycosylphosphatidylinositol (GPI) core structure, catalyzing the addition of a side chain ethanolamine phosphate to the alpha1,6-linked second mannose residue of the GPI lipid precursor; integral component of endoplasmic reticulum membrane; mutations affect cell wall integrity; homolog of human PIGG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    317284..319776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181495.1 → NP_012473.1  TPA: mannose-ethanolamine phosphotransferase LAS21 [Saccharomyces cerevisiae S288C]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWC0, P40367
    UniProtKB/TrEMBL
    B3LQ48, B5VLB4, C7GR50, C8ZBF2, N1P0V3
    Conserved Domains (2) summary
    COG1524
    Location:18 → 610
    Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
    cd16024
    Location:48 → 343
    GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40367.1

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