U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UTP18 Utp18p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853376, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
UTP18
Official Full Name
Utp18p
Primary source
SGD:S000003605
Locus tag
YJL069C
See related
AllianceGenome:SGD:S000003605; FungiDB:YJL069C; VEuPathDB:YJL069C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human UTP18 (UTP18 small subunit processome component). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See UTP18 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (310922..312706, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene acetyl-CoA:L-glutamate N-acetyltransferase Neighboring gene metallo-dependent hydrolase superfamily protein Neighboring gene S-formylglutathione hydrolase Neighboring gene Mpm1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis. Zhang C, et al. PLoS One, 2014. PMID 24466140, Free PMC Article
  2. Disruption of six ORFs on Saccharomyces cerevisiae chromosome X: the YJL069c gene of unknown function is essential to cell viability. Vandenbol M, et al. Yeast, 1999 Sep 30. PMID 10509023
  3. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits. Zhang C, et al. Nucleic Acids Res, 2016 Sep 6. PMID 27330138, Free PMC Article
  4. A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Champion EA, et al. Mol Cell Biol, 2008 Nov. PMID 18725399, Free PMC Article
  5. Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit. Braun CM, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31745560, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Pwp2p-containing subcomplex of 90S preribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Utp18p
NP_012466.1
  • Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    310922..312706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181502.1 → NP_012466.1  TPA: Utp18p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012466.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWB4, P40362
    UniProtKB/TrEMBL
    A6ZPQ4, B3LQ42, C8ZBE4, G2WGU8, N1P341
    Conserved Domains (2) summary
    sd00039
    Location:473 → 512
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:249 → 591
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40362.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous