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PRY3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853367, updated on 11-Sep-2024

Summary

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Official Symbol
PRY3
Primary source
SGD:S000003614
Locus tag
YJL078C
See related
AllianceGenome:SGD:S000003614; FungiDB:YJL078C; VEuPathDB:YJL078C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in fatty acid transport and sterol transport. Located in fungal-type cell wall. Orthologous to human GLIPR2 (GLI pathogenesis related 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (291336..293981, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Scp160p Neighboring gene sterol-binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ics3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of the transcription activator Ste12p as a repressor of PRY3 expression. Bickel KS, et al. Mol Cell Biol, 2006 Nov. PMID 16940175, Free PMC Article
  2. The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain. Cottier S, et al. Biol Open, 2020 Jul 2. PMID 32554483, Free PMC Article
  3. Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. Choudhary V, et al. Proc Natl Acad Sci U S A, 2012 Oct 16. PMID 23027975, Free PMC Article
  4. The pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is a fatty acid-binding protein. Darwiche R, et al. J Biol Chem, 2017 May 19. PMID 28365570, Free PMC Article
  5. The undertranslated transcriptome reveals widespread translational silencing by alternative 5' transcript leaders. Law GL, et al. Genome Biol, 2005. PMID 16420678, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pry3p
NP_012457.1
  • GPI-anchored cell wall protein involved in export of sterols; redundant role with PRY1 and PRY2 in the export of free fatty acids; role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    291336..293981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181511.1 → NP_012457.1  TPA: Pry3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012457.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWA5, P47033
    UniProtKB/TrEMBL
    B3LQ34, N1NZU2
    Conserved Domains (2) summary
    cd05384
    Location:24 → 152
    CAP_PRY1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins
    NF033849
    Location:598 → 855
    ser_rich_anae_1; serine-rich protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47033.1

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